| Gene Symbol |
Adipoq
|
| Entrez Gene |
11450
|
| Alt Symbol |
30kDa, APN, Acdc, Acrp30, Ad, GBP28, adipo, apM1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
adiponectin, C1Q and collagen domain containing
|
| Other Description |
30 kDa adipocyte complement-related protein|adipocyte complement related protein|adipocyte complement-related 30 kDa protein|adipocyte, C1Q and collagen domain containing|adipocyte, C1q and collagen domain-containing protein|adipocyte-specific protein AdipoQ|adiponectin
|
| Swissprots |
Q9DC68 Q60994 Q6GTX4 Q62400
|
| Accessions |
AAK13417 CBL63520 EDK97661 Q60994 AK003138 BAB22597 AK041214 BAC30866 AK134112 BAE22019 AX767955 CAE01097 AX767957 CAE01098 AY749429 AAW70555 AY754346 AAW82905 BC028770 AAH28770 U37222 AAA80543 U49915 AAB06706 NM_009605 NP_033735
|
| Function |
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269|PubMed:11479627, ECO:0000269|PubMed:11479628, ECO:0000269|PubMed:12840063, ECO:0000269|PubMed:15734737, ECO:0000269|PubMed:15760892}.
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Synthesized exclusively by adipocytes and secreted into plasma.
|
| Top Pathways |
Adipocytokine signaling pathway, Type II diabetes mellitus, PPAR signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway
|