MAD2L2

Gene Symbol	MAD2L2
Entrez Gene	10459
Alt Symbol	MAD2B, POLZ2, REV7
Species	Human
Gene Type	protein-coding
Description	MAD2 mitotic arrest deficient-like 2 (yeast)
Other Description	MAD2 (mitotic arrest deficient, yeast, homolog)-like 2|MAD2-like protein 2|REV7 homolog|hREV7|mitotic arrest deficient 2-like protein 2|mitotic arrest deficient homolog-like 2|mitotic spindle assembly checkpoint protein MAD2B|polymerase (DNA-directed), zeta 2, accessory subunit
Swissprots	Q9UNA7 Q9Y6I6 Q5TGW7 B3KNE3 Q9UI95
Accessions	AAY26393 EAW71697 EAW71698 EAW71699 Q9UI95 AF072933 AAD41647 AF080398 AAF20267 AF139365 AAD30290 AF157482 AAF34357 AK027327 BAG51305 AK094316 BAG52858 BC015244 AAH15244 BI517654 DQ891038 ABM81964 DQ894217 ABM85143 XM_011540507 XP_011538809 NM_001127325 NP_001120797 NM_006341 NP_006332
Function	Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. {ECO:0000269|PubMed:11459825, ECO:0000269|PubMed:11459826, ECO:0000269|PubMed:17296730, ECO:0000269|PubMed:17719540, ECO:00
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269|PubMed:11717438}.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis, Bacterial invasion of epithelial cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MAD2L2 Gene cDNA Clone - orb144169 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

Human-MAD2L2-cDNA-Clone - DC04049 from Abgent, a WuXi AppTec company Prices $284.85 Sizes 10 µg Species Human Accession BC015244

MAD2L2 - MBS1274951 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC015244

Human MAD2L2 cDNA clone(NM_001127325.1) - CDFH010859 from Creative Biomart Species Human Accession NM_001127325.1

Human MAD2L2 ORF Clone(NM_006341.3) - CDCL169414 from Creative Biomart Species Human Accession NM_006341.3

Human MAD2L2 ORF Clone(NM_001127325.1) - CDCR348608 from Creative Biomart Species Human Accession NM_001127325.1

Human MAD2L2 ORF Clone(NM_001127325.1) - CDCR348609 from Creative Biomart Species Human Accession NM_001127325.1

Human MAD2L2 Gene ORF cDNA clone in cloning vector - HG14678-G from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, N-His tag - HG14678-NH from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, N-HA tag - HG14678-NY from Sino Biological Species Human

Human MAD2L2 natural ORF mammalian expression plasmid, C-GFPSpark tag - HG14678-ACG from Sino Biological Species Human Accession BC015244

Human MAD2L2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG14678-CF from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG14678-ACR from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG14678-ANR from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG14678-NM from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, C-His tag - HG14678-CH from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG14678-CM from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG14678-ANG from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid - HG14678-UT from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, C-HA tag - HG14678-CY from Sino Biological Species Human

Human MAD2L2 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG14678-NF from Sino Biological Species Human

Human MAD2L2 ORF clone (NM_001127325.1) - CDCL129667 from Creative biogene Species Human

Human MAD2L2 ORF Clone (BC015244) - CDCS407787 from Creative biogene Species Human Accession Q9UI95

Human MAD2L2 ORF clone (BC015244) - CDCB158830 from Creative biogene Species Human

Human MAD2L2 cDNA Clone(NM_001127325.1) - CDFH010859 from Creative biogene Species Human

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