SPTLC2

Gene Symbol SPTLC2
Entrez Gene 9517
Alt Symbol HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a
Species Human
Gene Type protein-coding
Description serine palmitoyltransferase, long chain base subunit 2
Other Description LCB 2|SPT 2|long chain base biosynthesis protein 2a|serine palmitoyltransferase 2|serine palmitoyltransferase, subunit II|serine-palmitoyl-CoA transferase 2
Swissprots Q16685 O15270
Accessions AAD09621 EAW81297 EAW81298 EAW81299 O15270 AB011098 BAA25452 BC005123 AAH05123 BG024616 BM992457 BQ338973 DQ893297 ABM84223 DQ896786 ABM87785 U15555 AAC50871 W24363 Y08686 CAA69942 XM_011537384 XP_011535686 NM_004863 NP_004854
Function Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:20920666}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:17023427}.
Top Pathways Sphingolipid signaling pathway, Sphingolipid metabolism

SPTLC2 CRISPR/Cas9 KO Plasmid (h) - sc-403913 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC2 HDR Plasmid (h) - sc-403913-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC2 Double Nickase Plasmid (h) - sc-403913-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC2 Double Nickase Plasmid (h2) - sc-403913-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC2 CRISPR Activation Plasmid (h) - sc-403913-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC2 CRISPR Activation Plasmid (h2) - sc-403913-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC2 Lentiviral Activation Particles (h) - sc-403913-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC2 Lentiviral Activation Particles (h2) - sc-403913-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPTLC2 siRNA (h) - sc-106811 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPTLC2 shRNA Plasmid (h) - sc-106811-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPTLC2 shRNA (h) Lentiviral Particles - sc-106811-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Serine Palmitoyltransferase 2 RNAi - H00009517-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU120701 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20546 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20546 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SPTLC2 siRNA (Human) - CRH6323 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPTLC2 - MBS8236672 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPTLC2 (NM_004863.3) - SHH417548 from Creative biogene

Category siRNA
Species Reactivities Human

SPTLC2 shRNA Plasmid (Human) - CHH6323 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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