Gene Symbol | SPTLC2 |
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Entrez Gene | 9517 |
Alt Symbol | HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a |
Species | Human |
Gene Type | protein-coding |
Description | serine palmitoyltransferase, long chain base subunit 2 |
Other Description | LCB 2|SPT 2|long chain base biosynthesis protein 2a|serine palmitoyltransferase 2|serine palmitoyltransferase, subunit II|serine-palmitoyl-CoA transferase 2 |
Swissprots | Q16685 O15270 |
Accessions | AAD09621 EAW81297 EAW81298 EAW81299 O15270 AB011098 BAA25452 BC005123 AAH05123 BG024616 BM992457 BQ338973 DQ893297 ABM84223 DQ896786 ABM87785 U15555 AAC50871 W24363 Y08686 CAA69942 XM_011537384 XP_011535686 NM_004863 NP_004854 |
Function | Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:20920666}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:17023427}. |
Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |
SPTLC2 CRISPR/Cas9 KO Plasmid (h) - sc-403913 from Santa Cruz Biotechnology
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SPTLC2 HDR Plasmid (h) - sc-403913-HDR from Santa Cruz Biotechnology
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SPTLC2 Double Nickase Plasmid (h) - sc-403913-NIC from Santa Cruz Biotechnology
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SPTLC2 Double Nickase Plasmid (h2) - sc-403913-NIC-2 from Santa Cruz Biotechnology
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SPTLC2 CRISPR Activation Plasmid (h) - sc-403913-ACT from Santa Cruz Biotechnology
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SPTLC2 CRISPR Activation Plasmid (h2) - sc-403913-ACT-2 from Santa Cruz Biotechnology
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SPTLC2 Lentiviral Activation Particles (h) - sc-403913-LAC from Santa Cruz Biotechnology
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SPTLC2 Lentiviral Activation Particles (h2) - sc-403913-LAC-2 from Santa Cruz Biotechnology
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SPTLC2 siRNA (h) - sc-106811 from Santa Cruz Biotechnology
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SPTLC2 shRNA Plasmid (h) - sc-106811-SH from Santa Cruz Biotechnology
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SPTLC2 shRNA (h) Lentiviral Particles - sc-106811-V from Santa Cruz Biotechnology
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Serine Palmitoyltransferase 2 RNAi - H00009517-R01 from Novus Biologicals
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MISSION® esiRNA - EHU120701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20546 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20546 from Sigma-Aldrich
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SPTLC2 siRNA (Human) - CRH6323 from Cohesion Biosciences
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SPTLC2 - MBS8236672 from MyBioSource
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shRNA set against Human SPTLC2 (NM_004863.3) - SHH417548 from Creative biogene
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SPTLC2 shRNA Plasmid (Human) - CHH6323 from Cohesion Biosciences
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