| Gene Symbol |
Gls
|
| Entrez Gene |
24398
|
| Alt Symbol |
Glut, RATGLUT
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
glutaminase
|
| Other Description |
K-glutaminase|L-glutamine amidohydrolase|glutaminase kidney isoform, mitochondrial
|
| Swissprots |
P13264 Q8R421
|
| Accessions |
EDL99093 EDL99094 P13264 AY083459 AAM00020 CB776615 FQ216488 M22586 AAA41234 M65150 AAA41247 XM_008767075 XP_008765297 NM_001109968 NP_001103438 NM_012569 NP_036701
|
| Function |
Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain.
|
| Subcellular Location |
Isoform 1: Cytoplasm, cytosol {ECO:0000250}.
|
| Tissue Specificity |
Kidney, brain, and intestine.
|
| Top Pathways |
Central carbon metabolism in cancer, MicroRNAs in cancer, Glutamatergic synapse, GABAergic synapse, Proximal tubule bicarbonate reclamation
|