EPRS

Gene Symbol EPRS
Entrez Gene 2058
Alt Symbol EARS, GLUPRORS, PARS, PIG32, QARS, QPRS
Species Human
Gene Type protein-coding
Description glutamyl-prolyl-tRNA synthetase
Other Description bifunctional aminoacyl-tRNA synthetase|bifunctional glutamate/proline--tRNA ligase|cell proliferation-inducing gene 32 protein|glutamate tRNA ligase|glutamatyl-prolyl-tRNA synthetase|glutaminyl-tRNA synthetase|proliferation-inducing gene 32 protein|proliferation-inducing protein 32|proline tRNA ligase|proline-tRNA ligase|prolyl-tRNA synthetase
Swissprots B9EGH3 Q5H9S5 A0AVA9 Q6PD57 Q05BP6 Q5DSM1 Q05DF8 Q86X73 P07814
Accessions EAW93309 EAW93310 P07814 AA196283 AK296755 BAG59337 AK298192 BAG60462 AK307534 AY493416 AAS72877 BC015494 AAH15494 BC034797 AAH34797 BC046156 AAH46156 BC058921 AAH58921 BC067841 BC105983 AAI05984 BC126275 AAI26276 BC136465 AAI36466 CR933648 CAI45949 JQ080075 AFA28127 N85252 X07466 CAA30354 X54326 CAA38224 NM_004446 NP_004437
Function Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:1756734, ECO:0000269|PubMed:23071094}.
Subcellular Location Cytoplasm {ECO:0000305}.
Top Pathways Porphyrin and chlorophyll metabolism, Aminoacyl-tRNA biosynthesis

ProRS (A-2) - sc-393505 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ProRS (A-2): sc-393505. Western blot analysis of ProRS expression in Jurkat (A), HeLa (B), PANC-1 (C), HEK293 (D) and U-251-MG (E) whole cell lysates.

ProRS (F-3) - sc-514407 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ProRS (F-3): sc-514407. Western blot analysis of ProRS expression in A-431 (A), PANC-1 (B), Jurkat (C), HeLa (D), RT-4 (E) and U-251-MG (F) whole cell lysates.

ProRS (C-16) - sc-74860 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ProRS (D-12) - sc-393103 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ProRS (D-12): sc-393103. Western blot analysis of ProRS expression in Jurkat (A) and HeLa (B) whole cell lysates.

ProRS (H-300) - sc-367609 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ProRS (H-300): sc-367609. Western blot analysis of ProRS expression in Jurkat (A), PANC-1 (B), HeLa (D), A-431 (E) and Hs 181 Tes (F) whole cell lysates and mouse brain tissue extract (C).

ProRS (T-16) - sc-74863 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ProRS (T-16): sc-74863. Western blot analysis of ProRS expression in Jurkat (A), HEK293 (B) and HeLa (C) whole cell lysates.

ProRS (T-23) - sc-130855 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
ProRS (T-23): sc-130855. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.

Anti-Glutamyl Prolyl tRNA synthetase antibody - ab31531 from Abcam

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-Glutamyl Prolyl tRNA synthetase antibody (ab31531) at 1/10000 dilution + HEK293 cell line at 30 µg

Anti-Glutamyl Prolyl tRNA synthetase antibody - ab157122 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glutamyl Prolyl tRNA synthetase antibody (ab157122) at 0.1 µg/mlLane 1 : 293T whole cell lysateLane 2 : HeLa whole cell lysateLane 3 : Jurkat whole cell lysateLane 4 : TCMK1 whole cell lysateLane 5 : NIH 3T3 whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-Glutamyl Prolyl tRNA synthetase antibody - ab157128 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glutamyl Prolyl tRNA synthetase antibody (ab157128) at 0.1 µg/mlLane 1 : 293T cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-Glutamyl Prolyl tRNA synthetase antibody - ab157129 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Glutamyl Prolyl tRNA synthetase antibody (ab157129) at 0.1 µg/mlLane 1 : 293T whole cell lysateLane 2 : HeLa whole cell lysateLane 3 : Jurkat whole cell lysateLysates/proteins at 50 µg per lane.developed using the ECL technique

Anti-Glutamyl Prolyl tRNA synthetase antibody - N-terminal - ab71253 from Abcam

Prices $304.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Glutamyl Prolyl tRNA synthetase antibody - N-terminal (ab71253) + Jurkat cell lysate at 35 µg

Anti-EPRS / PARS Antibody (aa971-1020) - LS-C107783 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EPRS antibody LS-C107783 Western blot of PANC1 cell lysate.

Anti-EPRS / PARS Antibody (aa285-314) - LS-C100188 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with EPRS antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-EPRS / PARS Antibody (aa150-200) - LS-C290602 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EPRS by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-EPRS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-EPRS / PARS Antibody (aa950-1000) - LS-C290605 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse EPRS by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-EPRS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-EPRS / PARS Antibody (aa275-325) - LS-C290603 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EPRS by Western Blot. Samples: Whole cell lysate (50 ug) from 293T, HeLa, and Jurkat cells. Antibodies: Affinity purified rabbit anti-EPRS antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-EPRS / PARS Antibody (aa1440-1489) - LS-C102208 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
EPRS antibody LS-C102208 Western blot of 293T cell lysate.

EPRS Antibody - NBP1-84929 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EPRS Antibody [NBP1-84929] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

EPRS Antibody - NBP1-56557 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

EPRS Antibody - NBP2-22311 from Novus Biologicals

Prices $369.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: EPRS Antibody [NBP2-22311] - Whole cell lysate (50 ug) from 293T, HeLa, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. NBP2-22311 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 10 seconds.

EPRS Antibody - NBP1-84930 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: EPRS Antibody [NBP1-84930] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

EPRS Antibody - 45490002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Glutamyl Prolyl tRNA synthetase Antibody - bs-13393R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Formalin-fixed and paraffin embedded rat gastric tissue labeled with Anti-Glutamyl Prolyl tRNA synthetase/ProRS Polyclonal Antibody, Unconjugated (bs-13393R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
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