| Gene Symbol | EPRS |
|---|---|
| Entrez Gene | 2058 |
| Alt Symbol | EARS, GLUPRORS, PARS, PIG32, QARS, QPRS |
| Species | Human |
| Gene Type | protein-coding |
| Description | glutamyl-prolyl-tRNA synthetase |
| Other Description | bifunctional aminoacyl-tRNA synthetase|bifunctional glutamate/proline--tRNA ligase|cell proliferation-inducing gene 32 protein|glutamate tRNA ligase|glutamatyl-prolyl-tRNA synthetase|glutaminyl-tRNA synthetase|proliferation-inducing gene 32 protein|proliferation-inducing protein 32|proline tRNA ligase|proline-tRNA ligase|prolyl-tRNA synthetase |
| Swissprots | B9EGH3 Q5H9S5 A0AVA9 Q6PD57 Q05BP6 Q5DSM1 Q05DF8 Q86X73 P07814 |
| Accessions | EAW93309 EAW93310 P07814 AA196283 AK296755 BAG59337 AK298192 BAG60462 AK307534 AY493416 AAS72877 BC015494 AAH15494 BC034797 AAH34797 BC046156 AAH46156 BC058921 AAH58921 BC067841 BC105983 AAI05984 BC126275 AAI26276 BC136465 AAI36466 CR933648 CAI45949 JQ080075 AFA28127 N85252 X07466 CAA30354 X54326 CAA38224 NM_004446 NP_004437 |
| Function | Catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the multisynthetase complex and assembles into the GAIT complex which binds to stem loop- containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. {ECO:0000269|PubMed:15479637, ECO:0000269|PubMed:1756734, ECO:0000269|PubMed:23071094}. |
| Subcellular Location | Cytoplasm {ECO:0000305}. |
| Top Pathways | Porphyrin and chlorophyll metabolism, Aminoacyl-tRNA biosynthesis |