| Gene Symbol |
KAT2B
|
| Entrez Gene |
8850
|
| Alt Symbol |
CAF, P/CAF, PCAF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
K(lysine) acetyltransferase 2B
|
| Other Description |
CREBBP-associated factor|histone acetylase PCAF|histone acetyltransferase KAT2B|histone acetyltransferase PCAF|lysine acetyltransferase 2B|p300/CBP-associated factor
|
| Swissprots |
Q92831 Q6NSK1
|
| Accessions |
CAL00151 EAW64305 EAW64306 Q92831 AL832173 BC060823 AAH60823 BC070075 AAH70075 U57317 AAC50890 XM_005265528 XP_005265585 XM_011534206 XP_011532508 XR_245162 NM_003884 NP_003875
|
| Function |
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Also acetylates non-histone proteins, such as ACLY. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. {ECO:0000269|PubMed:10675335, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:23932781, ECO:0000269|PubMed:8684459, ECO:0000269|PubMed:9707565}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed but most abundant in heart and skeletal muscle. {ECO:0000269|PubMed:8684459}.
|
| Top Pathways |
Notch signaling pathway, HTLV-I infection, Viral carcinogenesis
|