| Gene Symbol | CBX3 |
|---|---|
| Entrez Gene | 11335 |
| Alt Symbol | HECH, HP1-GAMMA, HP1Hs-gamma |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromobox homolog 3 |
| Other Description | HP1 gamma homolog|chromobox homolog 3 (HP1 gamma homolog, Drosophila)|chromobox protein homolog 3|heterochromatin protein 1 homolog gamma|heterochromatin protein HP1 gamma|heterochromatin-like protein 1|modifier 2 protein |
| Swissprots | Q9P0Z6 Q9BVS3 Q99409 Q96CD7 Q13185 |
| Accessions | EAL24235 EAW93842 EAW93843 EAW93844 EAW93845 EAW93846 Q13185 AB030905 BAA83340 AF086270 AF136630 AAF62370 AL542267 BC000954 AAH00954 BC014380 AAH14380 BX647444 BX648807 CD514780 CV575477 DB565723 EU831928 ACE87369 EU832023 ACE86685 U26312 AAB48101 XM_005249611 XP_005249668 XM_005249612 XP_005249669 NM_007276 NP_009207 NM_016587 NP_057671 |
| Function | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. |
| Subcellular Location | Nucleus {ECO:0000305}. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). {ECO:0000305}. |