AKR7A2
| Gene Symbol | AKR7A2 |
|---|---|
| Entrez Gene | 8574 |
| Alt Symbol | AFAR, AFAR1, AFB1-AR1, AKR7 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) |
| Other Description | AFB1 aldehyde reductase 1|AFB1-AR 1|HEL-S-166mP|SSA reductase|aflatoxin B1 aldehyde reductase member 2|aflatoxin beta1 aldehyde reductase|aldoketoreductase 7|epididymis secretory sperm binding protein Li 166mP|succinic semialdehyde reductase |
| Swissprots | O75749 Q5TG63 O43488 |
| Accessions | EAW94881 O43488 AA037839 AF026947 AAC52104 AK225267 AK303131 BAG64236 AK310609 BC004111 AAH04111 BC007352 AAH07352 BC010852 AAH10852 BC011586 AAH11586 BC012171 AAH12171 BC013996 AAH13996 BG385885 BK000395 DAA00088 BM551906 BT007347 AAP36011 BU944847 DQ891003 ABM81929 DQ894182 ABM85108 EU794591 ACJ13645 Y16675 CAA76347 XR_946785 NM_003689 NP_003680 |
| Function | Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2- nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}. |
| Subcellular Location | Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:9576847}. |
| Tissue Specificity | Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed. {ECO:0000269|PubMed:10510318, ECO:0000269|PubMed:9576847}. |
| Top Pathways | Metabolism of xenobiotics by cytochrome P450 |
AKR7A2 CRISPR/Cas9 KO Plasmid (h) - sc-403377 from Santa Cruz Biotechnology
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AKR7A2 HDR Plasmid (h) - sc-403377-HDR from Santa Cruz Biotechnology
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AKR7A2 Double Nickase Plasmid (h) - sc-403377-NIC from Santa Cruz Biotechnology
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AKR7A2 Double Nickase Plasmid (h2) - sc-403377-NIC-2 from Santa Cruz Biotechnology
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AKR7A2 CRISPR Activation Plasmid (h) - sc-403377-ACT from Santa Cruz Biotechnology
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AKR7A2 CRISPR Activation Plasmid (h2) - sc-403377-ACT-2 from Santa Cruz Biotechnology
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AKR7A2 Lentiviral Activation Particles (h) - sc-403377-LAC from Santa Cruz Biotechnology
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AKR7A2 Lentiviral Activation Particles (h2) - sc-403377-LAC-2 from Santa Cruz Biotechnology
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AKR7A2 siRNA (h) - sc-44477 from Santa Cruz Biotechnology
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AKR7A2 shRNA Plasmid (h) - sc-44477-SH from Santa Cruz Biotechnology
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AKR7A2 shRNA (h) Lentiviral Particles - sc-44477-V from Santa Cruz Biotechnology
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AKR7A2 RNAi - H00008574-R01 from Novus Biologicals
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MISSION® esiRNA - EHU108661 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3032 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3032 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01633 from Sigma-Aldrich
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AKR7A2 siRNA (Human) - CRH5641 from Cohesion Biosciences
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AKR7A2 - MBS8213186 from MyBioSource
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shRNA set against Human AKR7A2 (NM_003689.3) - SHH234622 from Creative biogene
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AKR7A2 shRNA Plasmid (Human) - CHH5641 from Cohesion Biosciences
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AKR7A2 miRNA 3'UTR clone - MiUTR3H-05950 from Creative biogene
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