BCL3

Gene Symbol BCL3
Entrez Gene 602
Alt Symbol BCL4, D19S37
Species Human
Gene Type protein-coding
Description B-cell CLL/lymphoma 3
Other Description B-cell leukemia/lymphoma 3|B-cell lymphoma 3 protein|B-cell lymphoma 3-encoded protein|BCL-3|chronic lymphatic leukemia protein|proto-oncogene BCL3
Swissprots P20749
Accessions AAA51816 EAW57291 P20749 AK296180 BAH12275 AK309453 BC064993 AAH64993 BU501187 M31732 AAA51815 XM_011527197 XP_011525499 XM_011527198 XP_011525500 XM_011527199 XP_011525501 XM_011527200 XP_011525502 NM_005178 NP_005169
Function Contributes to the regulation of transcriptional activation of NF-kappa-B target genes. In the cytoplasm, inhibits the nuclear translocation of the NF-kappa-B p50 subunit. In the nucleus, acts as transcriptional activator that promotes transcription of NF-kappa-B target genes. Contributes to the regulation of cell proliferation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Ubiquitination via 'Lys- 63'-linked ubiquitin chains is required for nuclear accumulation. {ECO:0000250}.
Top Pathways TNF signaling pathway

Bcl-3 (C-14) - sc-185 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Bcl-3 (C-14): sc-185. Western blot analysis of Bcl-3 expression in NAMALWA (A) and WEHI-3 (B) whole cell lysates.

Bcl-3 (H-146) - sc-13038 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ChIP analysis of cofactor occupancy dynamics on the <i>KAI1</i> promoter in 293 cells in response to IL-1β treatment. Antibodies tested include NFκB p50 (C-19): sc-1190, NFκB p50 (E-10): sc-8414, NFκB p50 (H-119): sc-7178, NFκB p65 (C-20): sc-372, NFκB p65 (A): sc-109, NFκB p65 (H-286): sc-7151, HDAC3 (H-99): sc-11417, HDAC3 (N-19): sc-8138, Bcl-3 (C-14): sc-185, Bcl-3 (H-146): sc-13038. Data kindly provided by M.G. Rosenfeld and reproduced with permission from Baek <i>et al</i>., Cell 2002, 110: 55-67.

p-Bcl-3 (Ser 394/398) - sc-33883 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

p-Bcl-3 (Ser 419) - sc-33884 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-Bcl3 antibody - ab137499 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Bcl3 antibody (ab137499) at 1/1000 dilutionLane 1 : H1299 whole cell lysateLane 2 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Bcl3 antibody - ab27780 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Bcl3 antibody (ab27780) at 2 µg/ml + Jurkat

Anti-Bcl3 antibody - ab125217 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Bcl3 antibody - ab189621 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-Bcl3 antibody (ab189621) at 1/1000 dilution + total cell extracts from HeLa

Anti-Bcl3 antibody [1E8] - ab49470 from Abcam

Prices $385.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 1E8
ab49470, at a dilution of 1/25, staining Bcl3 oncoprotein in paraffin sections of normal human tonsil by immunohistochemistry. Note nuclear staining of a proportion of follicular cells, parafollicular cells and mucosa.ab49470, at a dilution of 1/25, staining Bcl3 oncoprotein in paraffin sections of normal human tonsil by immunohistochemistry. Note nuclear staining of a proportion of follicular cells, parafollicular cells and mucosa.

Anti-Bcl3 antibody [Ham150-3.5] - ab15046 from Abcam

Prices $376.00
Sizes 100 µg
Host Hamster
Clonality Monoclonal
Clone Ham150-3.5
Anti-Bcl3 antibody [Ham150-3.5] (ab15046) at 2 µg/ml

Anti-Bcl3 antibody - C-terminal - ab190508 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Bcl3 antibody - C-terminal (ab190508) at 1 µg/ml + 293 cell lysate at 15 µg

Anti-BCL3 / BCL-3 Antibody (Internal) - LS-C4131 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody (clone Ham150-3.5) - LS-C34551 from LifeSpan Bioscience

Prices $315.00
Sizes 250 µg
Host Hamster
Clonality Monoclonal
Clone Ham150-3.5

Anti-BCL3 / BCL-3 Antibody (aa248-277, Azide-free, HRP) - LS-C252499 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody (aa248-277, PE) - LS-C252500 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody (aa248-277, FITC) - LS-C252498 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody (aa127-376, Biotin) - LS-C298238 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody (aa127-376, FITC) - LS-C302395 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody - LS-C309603 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody - LS-C306531 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody - LS-C309602 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody (aa248-277) - LS-C329256 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-BCL3 / BCL-3 Antibody (clone 2069E2a) - LS-C184672 from LifeSpan Bioscience

Prices $335.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2069E2a
Western blot of immunized recombinant protein using BCL3 antibody. Left: BCL3 staining. Right: Coomassie Blue staining of immunized recombinant protein.

Anti-BCL3 / BCL-3 Antibody (aa82-341) - LS-C292980 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant BCL3 / BCL-3.

Anti-BCL3 / BCL-3 Antibody - LS-C346313 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot blot of extracts of various cell lines, using BCL3 antibody.
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