| Gene Symbol |
Mif
|
| Entrez Gene |
81683
|
| Alt Symbol |
-
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
|
| Other Description |
L-dopachrome isomerase|L-dopachrome tautomerase|glutathione-binding 13 kDa protein|macrophage migration inhibitory factor|phenylpyruvate tautomerase
|
| Swissprots |
P30904
|
| Accessions |
EDL97178 P30904 BC061545 AAH61545 FQ210474 FQ213295 FQ217414 FQ218686 FQ222835 FQ223656 FQ229019 FQ229084 S73424 AAB32392 U20999 AAA62644 U62326 AAB04024 NM_031051 NP_112313
|
| Function |
Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti- inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Expressed in a wide variety of organs including brain, spleen, liver, muscle and kidney.
|
| Top Pathways |
Phenylalanine metabolism, Tyrosine metabolism
|