| Gene Symbol |
gpt1
|
| Entrez Gene |
2541413
|
| Alt Symbol |
-
|
| Species |
S. pombe
|
| Gene Type |
protein-coding
|
| Description |
UDP-glucose-glycoprotein glucosyltransferase Gpt1
|
| Other Description |
-
|
| Swissprots |
Q09140
|
| Accessions |
CAC38351 Q09140 NM_001021188 NP_595281
|
| Function |
Selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER. Unfolded, denatured glycoproteins are substantially better substrates for glucosylation by this enzyme than are the corresponding native proteins. This protein and transient glucosylation may be involved in monitoring and/or assisting the folding and assembly of newly made glycoproteins, in order to identify glycoproteins that need assistance in folding from chaperones. {ECO:0000269|PubMed:8631292}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000269|PubMed:8631292}.
|
| Top Pathways |
Protein processing in endoplasmic reticulum
|