RPS6KB1

Gene Symbol	RPS6KB1
Entrez Gene	6198
Alt Symbol	PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70 S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha
Species	Human
Gene Type	protein-coding
Description	ribosomal protein S6 kinase, 70kDa, polypeptide 1
Other Description	p70 S6 kinase, alpha|ribosomal protein S6 kinase I|ribosomal protein S6 kinase beta-1|serine/threonine kinase 14 alpha|serine/threonine-protein kinase 14A
Swissprots	F6UYM1 E7ESB8 B4DTG1 B4DLT4 Q7Z721 B2R779 P23443
Accessions	CAM82744 CDL93497 EAW94382 EAW94383 EAW94384 P23443 AA424792 AI806441 AK026730 AK091503 AK293247 BAG56781 AK297147 BAG59646 AK300202 BAG61973 AK312875 BAG35726 BC030763 BC036033 AAH36033 BC053365 AAH53365 BG614269 BP359158 BQ719717 CA444907 CB050838 M60724 AAA36410 XM_006722010 XP_006722073 XM_011525101 XP_011523403 XM_011525102 XP_011523404 XM_011525103 XP_011523405 XM_011525104 XP_011523406 NM_001272042 NP_001258971 NM_001272043 NP_001258972 NM_001272044 NP_001258973 NM_001272060 NP_001258989 NM_003161 NP_003152
Function	Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mammalian target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein
Subcellular Location	Isoform Alpha II: Cytoplasm.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9804755}.
Top Pathways	Fc gamma R-mediated phagocytosis, Proteoglycans in cancer, Choline metabolism in cancer, AMPK signaling pathway, PI3K-Akt signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® p70/85 S6 Kinase siRNA II - 6572 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® p70/85 S6 Kinase siRNA I - 6566 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

p70 S6 kinase α CRISPR/Cas9 KO Plasmid (h) - sc-400162 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p70 S6 kinase α HDR Plasmid (h) - sc-400162-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p70 S6 kinase α Double Nickase Plasmid (h) - sc-400162-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p70 S6 kinase α Double Nickase Plasmid (h2) - sc-400162-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p70 S6 kinase α CRISPR Activation Plasmid (h) - sc-400162-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p70 S6 kinase α CRISPR Activation Plasmid (h2) - sc-400162-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

p70 S6 kinase α Lentiviral Activation Particles (h) - sc-400162-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p70 S6 kinase α Lentiviral Activation Particles (h2) - sc-400162-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

p70 S6 kinase α siRNA (h) - sc-36165 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p70 S6 kinase α shRNA Plasmid (h) - sc-36165-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p70 S6 kinase α shRNA (h) Lentiviral Particles - sc-36165-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p70 S6 kinase α siRNA (h2) - sc-44318 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p70 S6 kinase α shRNA Plasmid (h2) - sc-44318-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p70 S6 kinase α shRNA (h2) Lentiviral Particles - sc-44318-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

p70 S6 Kinase/S6K RNAi - H00006198-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU107461 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK2023 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2024 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK2022 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1380 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1304 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1303 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1380 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

Search more