PCK1

Gene Symbol PCK1
Entrez Gene 5105
Alt Symbol PEPCK-C, PEPCK1, PEPCKC
Species Human
Gene Type protein-coding
Description phosphoenolpyruvate carboxykinase 1 (soluble)
Other Description PEP carboxykinase|phosphoenolpyruvate carboxykinase, cytosolic|phosphoenolpyruvate carboxykinase, cytosolic [GTP]|phosphoenolpyruvate carboxylase|phosphopyruvate carboxylase
Swissprots Q8TCA3 A8K437 Q9UJD2 P35558 B4DT64
Accessions AAA02558 AAA91026 AAV50001 EAW75514 EAW75515 P35558 AI635748 AK290802 BAF83491 AK300072 BAG61876 AK303806 BAG64760 AW007566 BC023978 AAH23978 BJ993061 BM758256 BM768055 BX648510 DB187814 DQ893518 ABM84444 DQ896497 ABM87496 L05144 AAA60084 XM_011528839 XP_011527141 NM_002591 NP_002582
Function Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Subcellular Location Cytoplasm.
Tissue Specificity Major sites of expression are liver, kidney and adipocytes.
Top Pathways Glucagon signaling pathway, Glycolysis / Gluconeogenesis, AMPK signaling pathway, PI3K-Akt signaling pathway, Proximal tubule bicarbonate reclamation

PCK1 (D12F5) Rabbit mAb - 12940 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D12F5
Western blot analysis of extracts from various cell lines using PCK1 (D12F5) Rabbit mAb.

PEPCK (E-1) - sc-271204 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PEPCK (E-1) : sc-sc-271204. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skin tissue showing cytoplasmic staining of epidermal cells.

PEPCK (F-2) - sc-166778 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PEPCK (F-2): sc-166778. Western blot analysis of PEPCK expression in KNRK whole cell lysate.

PEPCK (F-3) - sc-271029 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PEPCK (F-3): sc-271029. Western blot analysis of PEPCK expression in A-431 (A), ZR-75-1 (B), Caki-1 (C), 293T (D) and c4 (E) whole cell lysates.

PEPCK-C (A-3) - sc-373972 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PEPCK-C (A-3): sc-373972. Western blot analysis of PEPCK-C expression in non-transfected: sc-117752 (A) and mouse PEPCK-C transfected: sc-127314 (B) 293T whole cell lysates.

PEPCK-C (F-11) - sc-377027 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PEPCK-C (F-11): sc-377027. Western blot analysis of PEPCK-C expression in non-transfected: sc-117752 (A) and mouse PEPCK-C transfected: sc-127314 (B) 293T whole cell lysates.

PEPCK-C (G-9) - sc-377136 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PEPCK-C (G-9): sc-377136. Western blot analysis of PEPCK-C expression in non-transfected: sc-117752 (A) and mouse PEPCK-C transfected: sc-127314 (B) 293T whole cell lysates.

PEPCK-C (H-44) - sc-135278 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PEPCK-C (H-44): sc-135278. Western blot analysis of PEPCK-C expression in mouse liver tissue extract.

PEPCK-C (I-17) - sc-74823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PEPCK-C (I-17): sc-74823. Western blot analysis of PEPCK-C expression in non-transfected: sc-117752 (A) and mouse PEPCK-C transfected: sc-127314 (B) 293T whole cell lysates.

PEPCK-C (P-14) - sc-74825 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PEPCK-C (P-14): sc-74825. Western blot analysis of PEPCK-C expression in Hep G2 (A), c4 (B), Caki-1 (C) and HeLa (D) whole cell lysates.

PEPCK-C (Q-21) - sc-130843 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
PEPCK-C (Q-21): sc-130843. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human hepatocarcinoma tissue showing cytoplasmic localization.

Anti-PCK1 antibody - ab70358 from Abcam

Prices $392.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PCK1 antibody (ab70358) at 1 µgLane 1 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 2 : Liver (Rat) Tissue LysateLane 3 : Liver (Mouse) Tissue LysateLane 4 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lysates/proteins at 10 µg per lane.SecondaryAnti-Rabbit IgG VHH Single Domain Antibody (HRP) (ab191866) at 1/50000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PCK1 antibody - ab55509 from Abcam

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PCK1 antibody - ab133176 from Abcam

Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Human uterus, endometrium tissue labelling PCK1 with ab133176 antibody at a concentration of 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen

Anti-PCK1 antibody - ab61701 from Abcam

Prices $378.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-PCK1 antibody (ab61701) at 0.5 µg/ml + Human Kidney lysate (35µg protein in RIPA buffer)

Anti-PCK1 antibody [EPR6938] - ab133603 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6938
All lanes : Anti-PCK1 antibody [EPR6938] (ab133603) at 1/10000 dilutionLane 1 : Human fetal kidney tissue lysateLane 2 : Human adipose tissue lysateSecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-PCK1 antibody [EPR6939] - ab125003 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR6939
All lanes : Anti-PCK1 antibody [EPR6939] (ab125003) at 1/1000 dilutionLane 1 : Human fetal kidney tissue lysate Lane 2 : Human adipose tissue lysate Lysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-PCK1 Antibody (aa592-622) - LS-C101194 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-PCK1 Antibody - LS-C331841 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human thyroid cancer using PCK1 antibody at dilution of 1:200 (200x lens).

Anti-PCK1 Antibody (aa513-524) IHC-plus™ - LS-B3032 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-PCK1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3032 concentration 2 ug/ml.

Anti-PCK1 Antibody (aa330-379) IHC-plus™ - LS-B1555 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PCK1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1555 concentration 5 ug/ml.

Anti-PCK1 Antibody (aa463-554) IHC-plus™ - LS-B11603 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-PCK1 Antibody (aa5-17) - LS-C9558 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PCK1 Antibody (N-Terminus) - LS-C80025 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Placenta lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-PCK1 Antibody (aa330-379) - LS-C31340 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
PCK1 antibody LS-C31340 was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.
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