PCK1

Gene Symbol PCK1
Entrez Gene 5105
Alt Symbol PEPCK-C, PEPCK1, PEPCKC
Species Human
Gene Type protein-coding
Description phosphoenolpyruvate carboxykinase 1 (soluble)
Other Description PEP carboxykinase|phosphoenolpyruvate carboxykinase, cytosolic|phosphoenolpyruvate carboxykinase, cytosolic [GTP]|phosphoenolpyruvate carboxylase|phosphopyruvate carboxylase
Swissprots Q8TCA3 A8K437 Q9UJD2 P35558 B4DT64
Accessions AAA02558 AAA91026 AAV50001 EAW75514 EAW75515 P35558 AI635748 AK290802 BAF83491 AK300072 BAG61876 AK303806 BAG64760 AW007566 BC023978 AAH23978 BJ993061 BM758256 BM768055 BX648510 DB187814 DQ893518 ABM84444 DQ896497 ABM87496 L05144 AAA60084 XM_011528839 XP_011527141 NM_002591 NP_002582
Function Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.
Subcellular Location Cytoplasm.
Tissue Specificity Major sites of expression are liver, kidney and adipocytes.
Top Pathways Glucagon signaling pathway, Glycolysis / Gluconeogenesis, AMPK signaling pathway, PI3K-Akt signaling pathway, Proximal tubule bicarbonate reclamation