PRKCE

Gene Symbol	PRKCE
Entrez Gene	5581
Alt Symbol	PKCE, nPKC-epsilon
Species	Human
Gene Type	protein-coding
Description	protein kinase C, epsilon
Other Description	protein kinase C epsilon type
Swissprots	Q9UE81 Q02156 Q53SM5 B0LPH7 Q53SL4 Q32MQ3
Accessions	AAD08855 AAX93119 AAX93253 AAY14773 ABY87556 AGC09605 EAX00257 EAX00258 EAX00259 Q02156 AK128749 AK313842 BAG36574 AL832345 BC029576 BC051195 BC054052 BC109033 AAI09034 BC109034 AAI09035 CA424727 X65293 CAA46388 XM_005264428 XP_005264485 XM_005264429 XP_005264486 XM_005264431 XP_005264488 XM_006712050 XP_006712113 XM_011532970 XP_011531272 XM_011532971 XP_011531273 XM_011532972 XP_011531274 XM_011532973 XP_011531275 XM_011532974 XP_011531276 XM_011532975 XP_011531277 XM_011532976 XP_011531278 XM_011532977 XP_011531279 XM_011532978 XP_011531280 XM_011532979 XP_011531281 XM_011532980 XP_011531282 XM_011532981 XP_011531283 XM_011532982 XP_011531284 XM_011532983 XP_011531285 XR_939695 NM_005400 NP_005391
Function	Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:17603037}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17603037}. Cell membrane {ECO:0000269|PubMed:17603037}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA- treated cells (By similarity). {ECO:0000250}.
Top Pathways	Vascular smooth muscle contraction, Sphingolipid signaling pathway, cGMP-PKG signaling pathway, Inflammatory mediator regulation of TRP channels, MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PKCε siRNA II - 12318 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® PKCε siRNA I - 7683 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

PKC ε siRNA (h) - sc-36251 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC ε shRNA Plasmid (h) - sc-36251-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC ε shRNA (h) Lentiviral Particles - sc-36251-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PKC epsilon RNAi - H00005581-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU118481 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK1828 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1829 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK1827 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1473 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1472 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1525 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1525 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1473 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1472 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

PRKCE siRNA (Human) - CRH3751 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PRKCE (NM_005400.2) - SHH382832 from Creative biogene Category siRNA Species Reactivities Human

PRKCE shRNA Plasmid (Human) - CHH3751 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

PRKCE miRNA 3'UTR clone - MiUTR1H-08274 from Creative biogene Species Reactivities Human

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