| Gene Symbol |
Htr2c
|
| Entrez Gene |
15560
|
| Alt Symbol |
5-HT2C, 5-HT2cR, 5-HTR2C, 5HT1c, Htr1c, SR1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
5-hydroxytryptamine (serotonin) receptor 2C
|
| Other Description |
5-HT-1C|5-HT-2C|5-HT1C|5-HT2C receptor|5-hydroxytryptamine receptor 1C|5-hydroxytryptamine receptor 2C|serotonin receptor 2C
|
| Swissprots |
Q5WRU6 P34968 B1ATN5
|
| Accessions |
AAA10521 EDL14710 P34968 AK034512 BAC28738 AK043320 AK079648 AK086348 BAC39653 AK139392 BC098327 BC141085 AAI41086 M63685 X72230 CAA51031 XM_006528706 XP_006528769 NM_008312 NP_032338
|
| Function |
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1- 2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release o
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Detected in brain cortex, hypothalamus, brainstem and arcuate nucleus. Detected in the paraventricular nucleus of the hypothalamus. {ECO:0000269|PubMed:17596444, ECO:0000269|PubMed:19038216, ECO:0000269|PubMed:7700379}.
|
| Top Pathways |
Gap junction, Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction
|