| Function |
Essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. Interacts with the cdc2 protein kinase to form MPF. Interaction with res2 promotes the phosphorylation of res1 and inhibits MBF-dependent gene transcription. Forms an autoregulating feedback-inhibition loop with MBF which is important for normal regulation of the cell cycle. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. Negatively regulates conjugation via interacting with cell cycle 'start' genes. Degraded by skp1, pop1 and pop2 in the G2 and M phases of the cell cycle. {ECO:0000269|PubMed:11163211, ECO:0000269|PubMed:11781565, ECO:0000269|PubMed:14970237, ECO:0000269|PubMed:7909513, ECO:0000269|PubMed:8264644, ECO:0000269|PubMed:8455610, ECO:0000269|PubMed:8657126}.
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![All lanes : Anti-Cig2 antibody [CIG 3A11/5] (ab10881) at 1/1000 dilutionLane 1 : 20ug untreated S. pombe wildtype cells, whole cell lysateLane 2 : 20ug S. pombe wildtype cells 8mM HU treated for 1 hour, whole cell lysateLane 3 : 20ug S. pombe wildtype cells 8mM HU treated for 2 hours, whole cell lysateLane 4 : 20ug S. pombe wildtype cells 8mM HU treated for 3 hours, whole cell lysateSecondaryHRP conjugated sheep anti-mouse antibodydeveloped using the ECL techniqueObserved band size : 50 kDa (why is the actual band size different from the predicted?)Exposure time : 1 minuteThis image is courtesy of an anonymous AbreviewSee Abreview](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_1/28949_ab10881_1.jpg)