PIK3CG

Gene Symbol PIK3CG
Entrez Gene 5294
Alt Symbol PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K
Species Human
Gene Type protein-coding
Description phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Other Description 1-phosphatidylinositol 3-kinase|PI3-kinase subunit gamma|phosphatidylinositol 3 kinase gamma, p110 gamma|phosphatidylinositol 3-kinase catalytic 110-kD gamma|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphoinositide-3-kinase gamma catalytic subunit|ptdIns-3-kinase subunit gamma|ptdIns-3-kinase subunit p110-gamma|serine/threonine protein kinase PIK3CG
Swissprots Q8IV23 Q9BZC8 A4D0Q6 P48736
Accessions AAQ96873 CCO13788 EAL24396 EAW83387 EAW83388 EAW83389 P48736 AA810265 AF327656 AAG61115 AK292684 BAF85373 AK313753 AY496423 AAS75801 BC035683 AAH35683 BX648341 X83368 CAA58284 XM_005250443 XP_005250500 XM_011516316 XP_011514618 XM_011516317 XP_011514619 NM_001282426 NP_001269355 NM_001282427 NP_001269356 NM_002649 NP_002640
Function Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin- based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:12163475}. Cell membrane {ECO:0000269|PubMed:12163475}.
Tissue Specificity Pancreas, skeletal muscle, liver and heart. {ECO:0000269|PubMed:7624799}.
Top Pathways Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

PI3 Kinase p110γ (D55D5) Rabbit mAb - 5405 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D55D5
Western blot analysis of extracts from NIH/3T3, Jurkat and K562 cells using PI3 Kinase p110γ (D55D5) Rabbit mAb.

PI3 Kinase p110γ Antibody - 4252 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562 and U937 cells, using PI3 Kinase p110γ Antibody.

PI 3-kinase p110γ (D-12) - sc-166365 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PI 3-kinase p110γ (D-12): sc-166365. Western blot analysis of PI 3-kinase p110γ expression in U-937 whole cell lysate.

PI 3-kinase p110γ (H-199) - sc-7177 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PI 3-kinase p110γ (H-199): sc-7177. Western blot analysis of PI 3-kinase p110γ expression in U-937 whole cell lysate.

PI 3-kinase p110γ (N-15) - sc-1405 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PI 3-kinase p110γ (N-16) - sc-1404 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PI 3-kinase p110γ (N-16): sc-1404. Western blot analysis of PI 3-kinase p110γ expression in non-transfected: sc-117752 (A) and human PI 3-kinase p110γ transfected: sc-115447 (B) 293T whole cell lysates.

Anti-PI 3 Kinase catalytic subunit gamma antibody - ab70912 from Abcam

Prices $385.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PI 3 Kinase catalytic subunit gamma antibody (ab70912) at 1/60 dilution + HeLa cell line lysate at 35 µgObserved band size : 126 kDa (why is the actual band size different from the predicted?)

Anti-PI 3 Kinase catalytic subunit gamma antibody - ab70903 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PI 3 Kinase catalytic subunit gamma antibody (ab70903) at 1/100 dilutionLane 1 : Non transfected 293 cell lysateLane 2 : PI 3 Kinase catalytic subunit transfected 293 cell lysateLysates/proteins at 2 µg per lane.

Anti-PI 3 Kinase catalytic subunit gamma antibody - ab65207 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PI 3 Kinase catalytic subunit gamma antibody (ab65207) at 1/60 dilution + CEM cell line lysates at 35 µg

Anti-PI 3 Kinase catalytic subunit gamma antibody - ab3537 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PI 3 Kinase catalytic subunit gamma antibody [4G10] - ab140307 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4G10
All lanes : Anti-PI 3 Kinase catalytic subunit gamma antibody [4G10] (ab140307) at 1/2000 dilutionLane 1 : HEK293T cell lysate were transfected with pCMV6-ENTRY control cDNA.Lane 2 : HEK293T cell lysate were transfected with pCMV6-ENTRY PI 3 Kinase catalytic subunit gamma cDNA.Lysates/proteins at 5 µg per lane.

Anti-PI 3 Kinase catalytic subunit gamma antibody [4H9] - ab139307 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H9
All lanes : Anti-PI 3 Kinase catalytic subunit gamma antibody [4H9] (ab139307) at 1/1000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY controlLane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY PI 3 Kinase catalytic subunit gamma cDNALysates/proteins at 5 µg per lane.

Anti-PI 3 Kinase catalytic subunit gamma antibody [6H5] - ab140310 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6H5
All lanes : Anti-PI 3 Kinase catalytic subunit gamma antibody [6H5] (ab140310) at 1/200 dilutionLane 1 : HepG2 cell extract (Human).Lane 2 : HeLa cell extract(Human).Lane 3 : SVT2 cell extract(Mouse). Lane 4 : A549 cell extract (Human).Lane 5 : COS7 cell extract (Monkey). Lane 6 : Jurkat cell extract (Human).Lane 7 : MDCK cell extract (Canine).Lane 8 : PC12 cell extract (Rat).Lane 9 : MCF7 cell extract (Human). Lysates/proteins at 35 µg per lane.

Anti-PI 3 Kinase catalytic subunit gamma antibody [Y388] - ab32089 from Abcam

Prices $99.00, $379.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y388
Overlay histogram showing HeLa cells stained with ab32089 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab32089, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-PI 3 Kinase catalytic subunit gamma antibody - C-terminal - ab154598 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PI 3 Kinase catalytic subunit gamma antibody - C-terminal (ab154598) at 1/500 dilutionLane 1 : Non-transfected 293T cell lysateLane 2 : PI 3 Kinase catalytic subunit gamma-transfected 293T cell lysate

Anti-PIK3CG / PI3K Gamma Antibody - LS-C26046 from LifeSpan Bioscience

Prices $485.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal

Anti-PIK3CG / PI3K Gamma Antibody - LS-C26045 from LifeSpan Bioscience

Prices $435.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-PIK3CG / PI3K Gamma Antibody (C-Terminus) - LS-C131598 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PIK3CG / PI3K Gamma Antibody (N-Terminus, clone Y388) - LS-C49578 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y388
Western blot analysis on Jurkat cell lysate using anti-PI3-kinase p110 subunit gamma (N-term) antibody, dilution 1:1000.

Anti-PIK3CG / PI3K Gamma Antibody (C-Terminus) - LS-C20191 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Staining (2 ug/ml) of Human Heart lysate (RIPA buffer, 30 ug total protein per lane). Primary incubated for 1 hour. Detected by chemiluminescence.

Anti-PIK3CG / PI3K Gamma Antibody (aa1074-1102) - LS-C99842 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

Anti-PIK3CG / PI3K Gamma Antibody (clone 4H9) - LS-C174225 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PIK3CG (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PIK3CG.

Anti-PIK3CG / PI3K Gamma Antibody (Ser1100) - LS-C100965 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-PIK3CG Antibody (S1100) (RB13319) in CEM cell line lysates (35 ug/lane). PIK3CG(arrow) was detected using the purified antibody.

Anti-PIK3CG / PI3K Gamma Antibody (aa518-547) - LS-C100964 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded skeletal muscle tissue reacted with PI3KCG antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-PIK3CG / PI3K Gamma Antibody - LS-C163727 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of PIK3CG Antibody in MDA-MB231 cell line lysates (35 ug/lane). PIK3CG (arrow) was detected using the purified antibody.
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