| Gene Symbol | PIK3CG |
|---|---|
| Entrez Gene | 5294 |
| Alt Symbol | PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
| Other Description | 1-phosphatidylinositol 3-kinase|PI3-kinase subunit gamma|phosphatidylinositol 3 kinase gamma, p110 gamma|phosphatidylinositol 3-kinase catalytic 110-kD gamma|phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma|phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform|phosphoinositide-3-kinase gamma catalytic subunit|ptdIns-3-kinase subunit gamma|ptdIns-3-kinase subunit p110-gamma|serine/threonine protein kinase PIK3CG |
| Swissprots | Q8IV23 Q9BZC8 A4D0Q6 P48736 |
| Accessions | AAQ96873 CCO13788 EAL24396 EAW83387 EAW83388 EAW83389 P48736 AA810265 AF327656 AAG61115 AK292684 BAF85373 AK313753 AY496423 AAS75801 BC035683 AAH35683 BX648341 X83368 CAA58284 XM_005250443 XP_005250500 XM_011516316 XP_011514618 XM_011516317 XP_011514619 NM_001282426 NP_001269355 NM_001282427 NP_001269356 NM_002649 NP_002640 |
| Function | Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin- based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:12163475}. Cell membrane {ECO:0000269|PubMed:12163475}. |
| Tissue Specificity | Pancreas, skeletal muscle, liver and heart. {ECO:0000269|PubMed:7624799}. |
| Top Pathways | Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway |