| Gene Symbol | Chrdl1 |
|---|---|
| Entrez Gene | 83453 |
| Alt Symbol | CHL, CHL1, Nrln1, VOPT |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | chordin-like 1 |
| Other Description | chordin-like protein 1|neuralin-1|neurogenesin-1|ventroptin-alpha|ventroptin-beta |
| Swissprots | Q924K0 Q920C1 Q9EPZ9 |
| Accessions | EDL14734 EDL14735 EDL14736 Q920C1 AF296451 AAK71523 AF305714 AAG27460 AF321853 AAK95586 AK142805 BAE25195 AK164661 BAE37864 BC050818 BC066832 AAH66832 XM_006529001 XP_006529064 XM_006529002 XP_006529065 XM_006529003 XP_006529066 NM_001114385 NP_001107857 NM_031258 NP_112548 |
| Function | Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity). {ECO:0000250}. |
| Subcellular Location | Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed in heart, brain, lung, liver, kidney and testis. |