| Gene Symbol |
Lias
|
| Entrez Gene |
79464
|
| Alt Symbol |
2900022L22Rik, 4933425M12Rik, 7a5ex, C77512, mLip1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
lipoic acid synthetase
|
| Other Description |
LS|lip-syn|lipoate synthase|lipoic acid synthase|lipoyl synthase, mitochondrial
|
| Swissprots |
Q99M04 Q543M1
|
| Accessions |
CBN72488 EDL37739 EDL37740 Q99M04 AB057731 BAB62009 AK013575 AK031851 BAC27579 AK045167 AK048744 BAC33443 AK049548 BAC33804 AK077192 BAC36672 BC002141 AAH02141 XM_006504194 XP_006504257 XM_006504195 XP_006504258 NM_024471 NP_077791
|
| Function |
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. {ECO:0000305}.
|
| Subcellular Location |
Mitochondrion {ECO:0000255|HAMAP- Rule:MF_03123, ECO:0000269|PubMed:11389890}.
|
| Tissue Specificity |
Expressed predominantly in heart, testis, and liver. {ECO:0000269|PubMed:11389890}.
|
| Top Pathways |
Lipoic acid metabolism
|