TRIP4
| Gene Symbol | TRIP4 |
|---|---|
| Entrez Gene | 9325 |
| Alt Symbol | ASC-1, ASC1, HsT17391, ZC2HC5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | thyroid hormone receptor interactor 4 |
| Other Description | TR-interacting protein 4|TRIP-4|activating signal cointegrator 1|thyroid receptor interacting protein 4|thyroid receptor-interacting protein 4|zinc finger, C2HC5-type |
| Swissprots | Q9UKH0 B2RAS0 Q15650 Q96ED7 |
| Accessions | EAW77684 EAW77685 Q15650 AK000433 AK314319 BAG36967 BC012448 AAH12448 BG166305 BQ225927 CA425850 EU446746 ABZ92275 L40371 AAC41738 XM_005254789 XP_005254846 XR_243130 NM_016213 NP_057297 |
| Function | Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B (PubMed:12077347). {ECO:0000250|UniProtKB:Q9QXN3, ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:25219498}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. Cytoplasm, cytosol {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. |
ASC-1 CRISPR/Cas9 KO Plasmid (h) - sc-405747 from Santa Cruz Biotechnology
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ASC-1 HDR Plasmid (h) - sc-405747-HDR from Santa Cruz Biotechnology
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ASC-1 Double Nickase Plasmid (h) - sc-405747-NIC from Santa Cruz Biotechnology
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ASC-1 Double Nickase Plasmid (h2) - sc-405747-NIC-2 from Santa Cruz Biotechnology
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ASC-1 CRISPR Activation Plasmid (h) - sc-405747-ACT from Santa Cruz Biotechnology
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ASC-1 CRISPR Activation Plasmid (h2) - sc-405747-ACT-2 from Santa Cruz Biotechnology
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ASC-1 Lentiviral Activation Particles (h) - sc-405747-LAC from Santa Cruz Biotechnology
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ASC-1 Lentiviral Activation Particles (h2) - sc-405747-LAC-2 from Santa Cruz Biotechnology
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ASC-1 siRNA (h) - sc-39159 from Santa Cruz Biotechnology
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ASC-1 shRNA Plasmid (h) - sc-39159-SH from Santa Cruz Biotechnology
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ASC-1 shRNA (h) Lentiviral Particles - sc-39159-V from Santa Cruz Biotechnology
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ASC1 RNAi - H00009325-R01 from Novus Biologicals
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MISSION® esiRNA - EHU013461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22031 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01621 from Sigma-Aldrich
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TRIP4 siRNA (Human) - CRH6170 from Cohesion Biosciences
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TRIP4 - MBS8235956 from MyBioSource
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ASC-1 CRISPR/Cas9 KO Plasmid (h2) - sc-405747-KO-2 from Santa Cruz Biotechnology
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ASC-1 HDR Plasmid (h2) - sc-405747-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human TRIP4 (NM_016213.4) - SHH435224 from Creative biogene
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TRIP4 shRNA Plasmid (Human) - CHH6170 from Cohesion Biosciences
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TRIP4 miRNA 3'UTR clone - MiUTR3H-06860 from Creative biogene
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