| Gene Symbol |
Clca1
|
| Entrez Gene |
23844
|
| Alt Symbol |
Clca2, Clca3, gob-5, gob5
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
chloride channel calcium activated 1
|
| Other Description |
calcium-activated chloride channel family member 3|calcium-activated chloride channel regulator 1|chloride channel calcium activated 2|chloride channel calcium activated 3|mCLCA3|protein gob-5
|
| Swissprots |
Q8R049 Q9D7Z6 O88826
|
| Accessions |
EDL12012 Q9D7Z6 AB017156 BAA33743 AK007466 AK008659 BAB25815 AK033560 AK136476 BAE22995 BC028343 AAH28343 BC116318 AAI16319 BC116319 AAI16320 XM_006501444 XP_006501507 NM_017474 NP_059502
|
| Function |
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269|PubMed:11296262, ECO:0000269|PubMed:11694454, ECO:0000269|PubMed:16645179}.
|
| Subcellular Location |
Secreted, extracellular space {ECO:0000269|PubMed:12019299, ECO:0000269|PubMed:15919655, ECO:0000269|PubMed:16895902}. Note=The 75 kDa N-terminal and a 35 kDa C-terminal products are fully secreted into extracellular environment as a soluble complex of two glycoproteins.
|
| Tissue Specificity |
Exclusively expressed in the digestive and respiratory tracts and in the uterus (at protein level). Expressed in small intestine, colon, stomach, and uterus and slightly expressed in trachea tissue. Exclusively expressed in the mucin granule membranes of gastrointestinal, respiratory, and uterine goblet cells and other mucin-producing cells. In the colon, expressed in the surface mucous cells. In the stomach highly expressed in the surface epithelium in the pylorus. Strongly expressed in the airway epithelium of lung tissues associated with airway hyperresponsiveness (AHR). {ECO:0000269|PubMed:10049711, ECO:0000269|PubMed:11296262, ECO:0000269|PubMed:12019299}.
|
| Top Pathways |
Olfactory transduction, Pancreatic secretion
|