EPS15

Gene Symbol	EPS15
Entrez Gene	2060
Alt Symbol	AF-1P, AF1P, MLLT5
Species	Human
Gene Type	protein-coding
Description	epidermal growth factor receptor pathway substrate 15
Other Description	ALL1 fused gene from chromosome 1|epidermal growth factor receptor substrate 15|protein AF-1p
Swissprots	P42566 D3DPJ2 B2R8J7 Q5SRH4
Accessions	CAR81473 CAS91489 EAX06822 EAX06823 EAX06824 P42566 AA789139 AF052132 AF331760 AK090936 BAG52249 AK129853 AK294297 BAH11726 AK308128 AK313396 BAG36194 AW949896 BC054006 AAH54006 BM681433 BX647676 CD657119 DA801048 DQ367924 ABD34786 U07707 AAA52101 Z29064 CAA82305 Z29070 XM_005270618 XP_005270675 XM_006710446 XP_006710509 XM_011540991 XP_011539293 NM_001159969 NP_001153441 NM_001981 NP_001972
Function	Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits.
Tissue Specificity	Ubiquitously expressed.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Eps15 siRNA I - 12253 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Eps15 CRISPR/Cas9 KO Plasmid (h) - sc-402303 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Eps15 HDR Plasmid (h) - sc-402303-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Eps15 Double Nickase Plasmid (h) - sc-402303-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Eps15 Double Nickase Plasmid (h2) - sc-402303-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Eps15 CRISPR Activation Plasmid (h) - sc-402303-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Eps15 CRISPR Activation Plasmid (h2) - sc-402303-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Eps15 Lentiviral Activation Particles (h) - sc-402303-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Eps15 Lentiviral Activation Particles (h2) - sc-402303-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Eps15 siRNA (h) - sc-35321 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Eps15 shRNA Plasmid (h) - sc-35321-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Eps15 shRNA (h) Lentiviral Particles - sc-35321-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

EPS15 RNAi - H00002060-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU082951 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7933 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7933 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

EPS15 siRNA (Human) - CRH1437 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EPS15 - MBS8218679 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human EPS15 (NM_001981.2) - SHH286649 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human EPS15(NM_001981.2) - SHH037091 from Creative biogene Category siRNA Species Reactivities Human

Human EPS15 siRNA - orb261939 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

EPS15 shRNA Plasmid (Human) - CHH1437 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

EPS15 miRNA 3'UTR clone - MiUTR1H-03277 from Creative biogene Species Reactivities Human

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