ACAN

Gene Symbol ACAN
Entrez Gene 176
Alt Symbol AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK
Species Human
Gene Type protein-coding
Description aggrecan
Other Description aggrecan core protein|cartilage-specific proteoglycan core protein|chondroitin sulfate proteoglycan core protein 1|large aggregating proteoglycan
Swissprots P16112 Q13650 Q9UCD3 Q9UCP4 Q9UCP5 Q9UDE0
Accessions AAB48068 AAC60643 AAD14782 AAD14783 AAD14784 AAD14785 AAD14786 AAD14788 AAD14789 AAD14791 AAD14792 AAD14793 AAD14794 AAD14795 AAD14796 AAD14797 AAD14798 AAD14799 AAD14800 AAD14801 AAD14802 AAD14804 AAD14805 AAD14806 AAD14807 AAD14808 AAD14809 AAD14810 AAD14811 AAD14812 AAD14814 AAD14815 AAD14816 CAI61688 EAX02017 EAX02018 EAX02019 EAX02020 EAX02021 P16112 AK290723 BAF83412 BC036445 AAH36445 BC150624 AAI50625 BQ182050 BQ446640 DA596050 J05062 AAA35726 L12234 M55172 AAA62824 U13192 X17406 CAA35463 X80278 XM_006720419 XP_006720482 XM_011521313 XP_011519615 XM_011521314 XP_011519616 NM_001135 NP_001126 NM_013227 NP_037359
Function This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.
Subcellular Location Secreted, extracellular space, extracellular matrix {ECO:0000250}.
Tissue Specificity Restricted to cartilages. {ECO:0000269|PubMed:7524681}.

aggrecan (D-20) - sc-16492 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

aggrecan (H-300) - sc-25674 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
aggrecan (H-300): sc-25674. Immunofluorescence staining of normal mouse intestine frozen section showing extracellular matrix staining.

aggrecan (E-12) - sc-67513 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
aggrecan (E-12): sc-67513. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cartilage tissue showing cytoplasmic staining of chondrocytes.

aggrecan (3H524) - sc-70333 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

aggrecan (3H525) - sc-70332 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

aggrecan (4F4) - sc-33695 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
aggrecan (4F4): sc-33695. Western blot analysis of aggrecan expression in human articular cartilage predigested with chondroitinase ABC , keratanase I and endo-β-galactosidase. Kindly provided by Dr. Roberto Perris, University of Parma, Italy.

aggrecan (5J14) - sc-70334 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

aggrecan/brevican (C-20) - sc-16493 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
aggrecan/brevican (C-20): sc-16493. Western blot analysis of aggrecan/brevican expression in HEK293 whole cell lysate.

aggrecan/brevican (D-4) - sc-166951 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
aggrecan/brevican (D-4): sc-166951. Western blot analysis of aggrecan/brevican expression in 293T (A), C6 (B) and HeLa (C) whole cell lysates.

aggrecan (N38) - sc-81542 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal

Anti-Aggrecan antibody - ab36861 from Abcam

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of Aggrecan staining in rat liver formalin fixed paraffin embedded tissue section, performed on a Leica Bond system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab36861, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

Anti-Aggrecan antibody - ab118610 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118610 at 3 &microg/ml staining Aggrecan in Formalin-fixed, Paraffin-embedded Human Cartilage tissue by Immunohistochemistry.

Anti-Aggrecan antibody [23A8] - ab194594 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 23A8

Anti-Aggrecan antibody [EPR14664] - ab186414 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14664
Immunohistochemical analysis of paraffin embedded Human cartilage tissue sections labeling Aggrecan using ab186414 at a 1/500 dilution. A ready to use HRP Polymer for Rabbit IgG was used as the secondary. Hematoxylin counterstain.

Anti-Aggrecan antibody - C-terminal - ab140691 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human cartilage tissue (after heat induced antigen retrieval) labelling Aggrecan with ab140691 at 10 µg/ml.

Anti-Aggrecan antibody - Cleaved Asp369 - ab53731 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Aggrecan antibody - Cleaved Asp369 (ab53731) at 1/500 dilutionLane 1 : Jurkat cell extracts treated with Etoposide (25µM, 60mins)Lane 2 : Jurkat cell extracts treated with Etoposide (25µM, 60mins) with immunising peptide

Anti-ACAN / Aggrecan Antibody (aa384-392, clone TS106) - LS-C191420 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TS106

Anti-ACAN / Aggrecan Antibody (N-Terminus) IHC-plus™ - LS-A1556 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ACAN / Aggrecan antibody LS-A1556 IHC of human bone, cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ACAN / Aggrecan Antibody (aa34-147) - LS-C292677 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-ACAN / Aggrecan Antibody (aa2162-2316, Biotin) - LS-C298095 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Aggrecan Antibody (C-Terminus) IHC-plus™ - LS-A1561 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ACAN / Aggrecan antibody LS-A1561 IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ACAN / Aggrecan Antibody (C-Terminus) IHC-plus™ - LS-A1562 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ACAN / Aggrecan antibody LS-A1562 IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ACAN / Aggrecan Antibody (Internal) IHC-plus™ - LS-A1559 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ACAN / Aggrecan antibody LS-A1559 IHC of human cartilage. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-ACAN / Aggrecan Antibody (clone 7D4) - LS-C187469 from LifeSpan Bioscience

Prices $575.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 7D4
Recombinant human aggrecan detected with Mouse anti-Human Aggrecan followed by Goat anti-Mouse IgG:Dylight800. Visualized using a LI-COR Odyssey infrared imaging system

Anti-ACAN / Aggrecan Antibody (aa34-147, Biotin) - LS-C298097 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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