| Gene Symbol | Nr1h4 |
|---|---|
| Entrez Gene | 20186 |
| Alt Symbol | AI957360, Fxr, HRR1, RIP14, Rxrip14 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 1, group H, member 4 |
| Other Description | RXR-interacting protein 14|bile acid receptor|farnesoid X activated receptor|farnesoid X-activated receptor|farnesol receptor HRR-1|retinoid X receptor-interacting protein 14 |
| Swissprots | Q60642 Q60643 E9QJW2 Q60641 |
| Accessions | AAK15460 AAQ73843 AAQ73844 EDL21500 EDL21501 EDL21502 Q60641 AK002513 AK050566 AK132255 BAE21061 BC015261 AAH15261 U09416 AAC53066 U09417 AAC53065 U09418 AAC52978 XM_006513391 XP_006513454 XM_006513393 XP_006513456 NM_001163504 NP_001156976 NM_001163700 NP_001157172 NM_009108 NP_033134 |
| Function | Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) and activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 within its gene locus (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000305}. |
| Tissue Specificity | Expressed specifically in liver and kidney. |
| Top Pathways | Bile secretion |
Mouse Nr1h4 cDNA clone(NM_001163504.1) - CDFG020318 from Creative Biomart
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Mouse Nr1h4 cDNA clone(NM_001163700.1) - CDFG020481 from Creative Biomart
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Mouse NR1H4 ORF clone(NM_009108.2) - CDCH392214 from Creative Biomart
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Mouse NR1H4 ORF clone(NM_001163700.1) - CDCH392215 from Creative Biomart
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Mouse NR1H4 ORF clone(NM_001163504.1) - CDCH392216 from Creative Biomart
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Mouse Nr1h4 ORF Clone(NM_009108.2) - CDCL171058 from Creative Biomart
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Mouse Nr1h4 ORF Clone(NM_001163504.1) - CDCL171059 from Creative Biomart
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Mouse Nr1h4 ORF Clone(NM_001163504.1) - CDCR239864 from Creative Biomart
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Mouse Nr1h4 ORF Clone(NM_001163504.1) - CDCR239865 from Creative Biomart
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Mouse Nr1h4 ORF Clone(NM_001163700.1) - CDCR240060 from Creative Biomart
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Mouse Nr1h4 ORF Clone(NM_001163700.1) - CDCR240061 from Creative Biomart
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Mouse Nr1h4 ORF Clone(NM_009108.2) - CDCR382906 from Creative Biomart
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Mouse Nr1h4 ORF Clone(NM_009108.2) - CDCR382906 from Creative biogene
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Human Nr1h4 ORF clone (NM_001163504.1) - CDCL139669 from Creative biogene
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Human Nr1h4 ORF clone (NM_001163700.1) - CDCL139671 from Creative biogene
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Mouse Nr1h4 cDNA Clone(NM_001163504.1) - CDFG020318 from Creative biogene
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Mouse Nr1h4 cDNA Clone(NM_001163700.1) - CDFG020481 from Creative biogene
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