| Gene Symbol | icmA-2 |
|---|---|
| Entrez Gene | 8619243 |
| Alt Symbol | DDBDRAFT_0217410, DDBDRAFT_0252724, DDB_0217410, DDB_0252724 |
| Species | Dictyostelium discoideum |
| Gene Type | protein-coding |
| Description | prenylcysteine methyltransferase |
| Other Description | protein-S-isoprenylcysteine O-methyltransferase |
| Swissprots | Q86AM7 Q558K8 Q8T623 |
| Accessions | XM_639264 XP_644356 |
| Function | Methylates the C-terminal cysteine residues of small GTPases and the heterotrimeric G protein gamma subunit in response to cAMP. The methylation is required for intercellular signaling and regulation of cAMP waves propagation. It also seems to induce the activity of car1, a G protein-coupled receptor which senses extracellular cAMP during the aggregation phase of development. {ECO:0000269|PubMed:17699599}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Top Pathways | Terpenoid backbone biosynthesis |