| Gene Symbol |
AASDHPPT
|
| Entrez Gene |
60496
|
| Alt Symbol |
AASD-PPT, CGI-80, LYS2, LYS5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
|
| Other Description |
4'-phosphopantetheinyl transferase|L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase|LYS5 ortholog|alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase
|
| Swissprots |
B4DDW7 Q9UG80 Q9P0Q3 Q9C068 B2R6D1 Q9NRN7 Q9Y389
|
| Accessions |
EAW67077 EAW67078 Q9NRN7 AB072896 AF136978 AAG49439 AF151057 AAF36143 AF151838 AAD34075 AF201943 AAF86879 AF302110 AAG30872 AK293362 BAG56878 AK312529 BAG35428 AL050073 CAB43257 BC015470 AAH15470 BC016728 AAH16728 BX537665 DQ891342 ABM82268 DQ894524 ABM85450 NM_015423 NP_056238
|
| Function |
Catalyzes the post-translational modification of target proteins by phosphopantetheine. Can transfer the 4'- phosphopantetheine moiety from coenzyme A to a serine residue of a broad range of acceptors, such as the acyl carrier domain of FASN. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048, ECO:0000269|PubMed:18022563}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12815048}.
|
| Tissue Specificity |
Detected in heart, skeletal muscle, placenta, testis, brain, pancreas, liver and kidney. {ECO:0000269|PubMed:11286508, ECO:0000269|PubMed:12815048}.
|
| Top Pathways |
Pantothenate and CoA biosynthesis
|
