KCNN4

Gene Symbol KCNN4
Entrez Gene 3783
Alt Symbol IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4
Species Human
Gene Type protein-coding
Description potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
Other Description SKCa 4|SKCa4|intermediate conductance calcium-activated potassium channel protein 4|potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4|putative Gardos channel|putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel|small conductance calcium-activated potassium channel 4
Swissprots Q53XR4 O15554
Accessions AAG26917 CAB70490 CBM42811 EAW57229 EAW57230 O15554 AB128983 BAI52725 AB128984 BAI52726 AB128985 BAI52727 AF000972 AAB82739 AF022150 AAC23541 AF022797 AAC51913 AF033021 AAC36804 AF053403 AAC35281 AF395661 AAK81862 BC015337 AAH15337 BT007426 AAP36094 DQ891493 ABM82419 DQ894684 ABM85610 XM_005258882 XP_005258939 XM_005258883 XP_005258940 XM_011526938 XP_011525240 XR_935823 NM_002250 NP_002241
Function Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. {ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:18796614}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed in non-excitable tissues.
Top Pathways Salivary secretion, Protein digestion and absorption

IK1 CRISPR/Cas9 KO Plasmid (h) - sc-402139 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IK1 HDR Plasmid (h) - sc-402139-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IK1 Double Nickase Plasmid (h) - sc-402139-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IK1 Double Nickase Plasmid (h2) - sc-402139-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IK1 CRISPR Activation Plasmid (h) - sc-402139-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IK1 CRISPR Activation Plasmid (h2) - sc-402139-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IK1 Lentiviral Activation Particles (h) - sc-402139-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IK1 Lentiviral Activation Particles (h2) - sc-402139-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IK1 siRNA (h) - sc-72200 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IK1 shRNA Plasmid (h) - sc-72200-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IK1 shRNA (h) Lentiviral Particles - sc-72200-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KCNN4 RNAi - H00003783-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU035251 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10984 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10984 from Sigma-Aldrich

Category ZFN Kit
Prices $4,120.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04526 from Sigma-Aldrich

Category miRNA

KCNN4 siRNA (Human) - CRH2557 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human KCNN4 (NM_002250.2) - SHH323623 from Creative biogene

Category siRNA
Species Reactivities Human

KCNN4 shRNA Plasmid (Human) - CHH2557 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KCNN4 miRNA 3'UTR clone - MiUTR1H-05162 from Creative biogene

Species Reactivities Human
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