Gene Symbol | S100P |
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Entrez Gene | 6286 |
Alt Symbol | MIG9 |
Species | Human |
Gene Type | protein-coding |
Description | S100 calcium binding protein P |
Other Description | S100 calcium-binding protein P|migration-inducing gene 9 protein|protein S100-E|protein S100-P |
Swissprots | Q5J7W2 P25815 |
Accessions | EAW82384 P25815 AF539739 AAO41114 AI202505 AY423724 AAS00487 BC006819 AAH06819 BI259919 BT007289 AAP35953 DQ891088 ABM82014 DQ894270 ABM85196 X65614 CAA46566 NM_005980 NP_005971 |
Function | May function as calcium sensor and contribute to cellular calcium signaling. In a calcium-dependent manner, functions by interacting with other proteins, such as EZR and PPP5C, and indirectly plays a role in physiological processes like the formation of microvilli in epithelial cells. May stimulate cell proliferation in an autocrine manner via activation of the receptor for activated glycation end products (RAGE). {ECO:0000269|PubMed:14617629, ECO:0000269|PubMed:19111582, ECO:0000269|PubMed:22399290}. |
Subcellular Location | Nucleus. Cytoplasm. Cell projection, microvillus membrane. Note=Colocalizes with S100PBP in the nucleus. Colocolizes with EZR in the microvilli in a calcium- dependent manner. |
Tissue Specificity | Detected in all of the tissues except brain, testis and small intestine, expression level is higher in placenta, heart, lung, skeletal muscle, spleen and leukocyte. Up- regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. {ECO:0000269|PubMed:14672411, ECO:0000269|PubMed:15632002}. |
SignalSilence ® S100P siRNA II - 12114 from Cell Signaling Technology
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SignalSilence ® S100P siRNA I - 12118 from Cell Signaling Technology
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S-100P CRISPR/Cas9 KO Plasmid (h) - sc-404366 from Santa Cruz Biotechnology
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S-100P HDR Plasmid (h) - sc-404366-HDR from Santa Cruz Biotechnology
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S-100P Double Nickase Plasmid (h) - sc-404366-NIC from Santa Cruz Biotechnology
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S-100P Double Nickase Plasmid (h2) - sc-404366-NIC-2 from Santa Cruz Biotechnology
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S-100P CRISPR Activation Plasmid (h) - sc-404366-ACT from Santa Cruz Biotechnology
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S-100P CRISPR Activation Plasmid (h2) - sc-404366-ACT-2 from Santa Cruz Biotechnology
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S-100P Lentiviral Activation Particles (h) - sc-404366-LAC from Santa Cruz Biotechnology
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S-100P Lentiviral Activation Particles (h2) - sc-404366-LAC-2 from Santa Cruz Biotechnology
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S-100P siRNA (h) - sc-61488 from Santa Cruz Biotechnology
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S-100P shRNA Plasmid (h) - sc-61488-SH from Santa Cruz Biotechnology
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S-100P shRNA (h) Lentiviral Particles - sc-61488-V from Santa Cruz Biotechnology
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S100P RNAi - H00006286-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN18798 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18798 from Sigma-Aldrich
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S100P siRNA (Human) - CRH4234 from Cohesion Biosciences
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S100P - MBS8211379 from MyBioSource
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S100P shRNA Plasmid (Human) - CHH4234 from Cohesion Biosciences
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