| Gene Symbol | CDC42 |
|---|---|
| Entrez Gene | 998 |
| Alt Symbol | CDC42Hs, G25K |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle 42 |
| Other Description | G25K GTP-binding protein|GTP binding protein, 25kDa|GTP-binding protein, 25kD|cell division control protein 42 homolog|dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))|dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))|growth-regulating protein|small GTP binding protein CDC42 |
| Swissprots | Q9UDI2 Q7L8R5 P60953 P21181 P25763 |
| Accessions | AAT70721 CAE93985 CAI61729 EAW95002 EAW95003 EAW95004 EAW95005 EAW95006 EAW95007 EAW95008 EAW95009 P60953 AF498962 AAM21109 AF498963 AAM21110 AK297465 BAG59887 AK303994 BAG64911 AK311375 AK316449 BAH14820 AL121734 CAB57325 AL121735 CAB57326 AL121736 CAB57327 AL121737 CAB57328 BC002711 AAH02711 BC003682 AAH03682 BC018266 AAH18266 BC018622 BM684474 BP871988 DQ596760 DQ891195 ABM82121 DQ894377 ABM85303 M35543 AAA52494 M57298 AAA52592 NM_001039802 NP_001034891 NM_001791 NP_001782 NM_044472 NP_426359 |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. {ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:17038317}. |
| Subcellular Location | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase. Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells. Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1. Colocalizes with NEK6 in the centrosome. |
| Top Pathways | Adherens junction, Endocytosis, Rap1 signaling pathway, Chemokine signaling pathway, Non-alcoholic fatty liver disease (NAFLD) |