| Gene Symbol |
Ntn1
|
| Entrez Gene |
114523
|
| Alt Symbol |
netrin-1
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
netrin 1
|
| Other Description |
netrin-1
|
| Swissprots |
Q924Z9
|
| Accessions |
EDM04807 EDM04808 Q924Z9 AY028417 AAK17014 Y11353 CAA72188 XM_006246567 XP_006246629 XM_006246568 XP_006246630 NM_053731 NP_446183
|
| Function |
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in colorectal tumorigenesis by regulating apoptosis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
| Top Pathways |
Axon guidance
|