CTCF

Gene Symbol	CTCF
Entrez Gene	10664
Alt Symbol	MRD21
Species	Human
Gene Type	protein-coding
Description	CCCTC-binding factor (zinc finger protein)
Other Description	11 zinc finger transcriptional repressor|11-zinc finger protein|CTCFL paralog|transcriptional repressor CTCF
Swissprots	Q59EL8 Q53XI7 B5MC38 P49711
Accessions	AAF31318 CAH05607 EAW83142 EAW83143 EAW83144 EAW83145 EAW83146 P49711 AA814313 AB209793 BAD93030 AI753629 AK093395 BAG52706 AK314804 BC014267 AAH14267 BT009915 AAP88917 DB229066 DQ895834 ABM86760 EU176369 ABW03820 U25435 AAB07788 XM_005255775 XP_005255832 NM_001191022 NP_001177951 NM_006565 NP_006556
Function	Chromatin binding factor that binds to DNA sequence specific sites. Involved in transcriptional regulation by binding to chromatin insulators and preventing interaction between promoter and nearby enhancers and silencers. Acts as transcriptional repressor binding to promoters of vertebrate MYC gene and BAG1 gene. Also binds to the PLK and PIM1 promoters. Acts as a transcriptional activator of APP. Regulates APOA1/C3/A4/A5 gene cluster and controls MHC class II gene expression. Plays an essential role in oocyte and preimplantation embryo development by activating or repressing transcription. Seems to act as tumor suppressor. Plays a critical role in the epigenetic regulation. Participates in the allele-specific gene expression at the imprinted IGF2/H19 gene locus. On the maternal allele, binding within the H19 imprinting control region (ICR) mediates maternally inherited higher-order chromatin conformation to restrict enhancer access to IGF2. Plays a critical role in gene silencing over
Subcellular Location	Nucleus, nucleoplasm. Chromosome. Chromosome, centromere. Note=May translocate to the nucleolus upon cell differentiation. Associates with both centromeres and chromosomal arms during metaphase. Associates with the H19 ICR in mitotic chromosomes. May be preferentially excluded from heterochromatin during interphase.
Tissue Specificity	Ubiquitous. Absent in primary spermatocytes. {ECO:0000269|PubMed:9591631}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® CTCF siRNA I - 6265 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

CTCF CRISPR/Cas9 KO Plasmid (h) - sc-401245 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CTCF HDR Plasmid (h) - sc-401245-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CTCF Double Nickase Plasmid (h) - sc-401245-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CTCF Double Nickase Plasmid (h2) - sc-401245-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CTCF CRISPR Activation Plasmid (h) - sc-401245-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CTCF CRISPR Activation Plasmid (h2) - sc-401245-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CTCF Lentiviral Activation Particles (h) - sc-401245-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CTCF Lentiviral Activation Particles (h2) - sc-401245-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CTCF siRNA (h) - sc-35124 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CTCF shRNA Plasmid (h) - sc-35124-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CTCF shRNA (h) Lentiviral Particles - sc-35124-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CTCF RNAi - H00010664-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU130111 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6721 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6721 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08702 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08702

CTCF siRNA (Human) - CRH7271 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CTCF - MBS8222521 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CTCF (NM_006565.3) - SHH271073 from Creative biogene Category siRNA Species Reactivities Human

CTCF shRNA Plasmid (Human) - CHH7271 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CTCF miRNA 3'UTR clone - MiUTR3H-06610 from Creative biogene Species Reactivities Human

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