| Gene Symbol | EFNB2 |
|---|---|
| Entrez Gene | 1948 |
| Alt Symbol | EPLG5, HTKL, Htk-L, LERK5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ephrin-B2 |
| Other Description | HTK ligand|LERK-5|eph-related receptor tyrosine kinase ligand 5|ligand of eph-related kinase 5 |
| Swissprots | P52799 Q5JV56 |
| Accessions | CAD91556 EAX09085 P52799 BC069342 AAH69342 BC074856 AAH74856 BC074857 AAH74857 BC105955 AAI05956 BC105956 AAI05957 BC105957 AAI05958 BG741114 BQ029549 BQ433342 BQ708550 BU622947 CB998384 DR004737 HQ448461 ADQ32941 L38734 AAC41752 U16797 AAA99707 U81262 AAD03786 NM_004093 NP_004084 |
| Function | Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Lung and kidney. |
| Top Pathways | Axon guidance |