Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel

Name Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel
Supplier Creative Biolabs
Catalog AGTO-G022G
Applications Cytotoxic Assay FA
Species Reactivities Human
SwissProt/Accession P04626
Gene ERBB2
Description This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 scFv to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating SK-OV-3 tumor xenografts.
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