ERBB2

Gene Symbol	ERBB2
Entrez Gene	2064
Alt Symbol	CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Species	Human
Gene Type	protein-coding
Description	erb-b2 receptor tyrosine kinase 2
Other Description	c-erb B2/neu protein|herstatin|human epidermal growth factor receptor 2|metastatic lymph node gene 19 protein|neuro/glioblastoma derived oncogene homolog|neuroblastoma/glioblastoma derived oncogene homolog|p185erbB2|proto-oncogene Neu|proto-oncogene c-ErbB-2|receptor tyrosine-protein kinase erbB-2|tyrosine kinase-type cell surface receptor HER2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2|v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2|v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Swissprots	B4DHN3 B2RZG3 Q9UMK4 X5D2V5 Q6LDV1 Q14256 P04626
Accessions	AAA35809 AAA35978 AAA58637 AAC37531 AAD15229 AAF30295 AAO18082 BAE15959 BAE15960 CCA94568 CCQ77584 EAW60595 EAW60596 EAW60597 P04626 AB025286 AF177761 AAD56009 AK131568 AK295195 BAG58195 AK296908 BAG59464 AK300321 BAG62073 AK309029 AK313683 BC080193 BC110392 BC156755 AAI56756 BC167147 AAI67147 BI755753 BM678576 CN409735 DC346286 HM437238 ADN43069 HY033940 KJ534831 AHW56471 KJ534832 AHW56472 KJ534964 AHW56604 M11730 AAA75493 S57296 AAD14920 X03363 CAA27060 NM_001005862 NP_001005862 NM_001289936 NP_001276865 NM_001289937 NP_001276866 NM_001289938 NP_001276867 NM_004448 NP_004439 NR_110535
Function	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Subcellular Location	Isoform 3: Cytoplasm. Nucleus.
Tissue Specificity	Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO:0000269|PubMed:15380516}.
Top Pathways	Proteoglycans in cancer, MicroRNAs in cancer, Central carbon metabolism in cancer, Adherens junction, Calcium signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active ErbB 2 protein - ab60866 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Insect cells

Active human ErbB 2 (biotinylated ) protein fragment - ab200500 from Abcam Category Protein Prices $760.00 Sizes 25 µg Source HEK 293 cells Species Human

Active human ErbB 2 (mutated ) protein fragment - ab190418 from Abcam Category Protein Prices $506.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human ErbB 2 (mutated G776 V + G776 C) protein fragment - ab191466 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human ErbB 2 protein fragment - ab168896 from Abcam Category Protein Prices $302.00 Sizes 100 µg Source HEK 293 cells Species Human

Active human ErbB 2 protein fragment - ab182691 from Abcam Category Protein Prices $372.00 Sizes 50 µg Source HEK 293 cells Species Human

ErbB 2 peptide - ab2429 from Abcam Category Peptide Prices $181.00 Sizes 500 µl

Human ErbB 2 peptide - ab38954 from Abcam Category Peptide

Human ErbB 2 peptide - ab38955 from Abcam Category Peptide

Human ErbB 2 protein fragment - ab40048 from Abcam Category Protein Source E. coli Species Human

Human ErbB 2 protein fragment - ab63288 from Abcam Category Protein Source E. coli Species Human

Human ErbB 2 protein fragment - ab194022 from Abcam Category Protein Source Mammalian Species Human

Human Herstatin protein fragment - ab203527 from Abcam Category Protein Source E. coli Species Human

Mouse ErbB 2 protein fragment - ab168691 from Abcam Category Protein Source HEK 293 cells Species Mouse

Rat ErbB 2 protein fragment - ab191967 from Abcam Category Protein Source E. coli Species Rat

ERBB2 / HER2 Blocking Peptide - LS-E3744 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Blocking Peptide - LS-E7507 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Blocking Peptide - LS-E7508 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Blocking Peptide - LS-E7509 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Blocking Peptide - LS-E7510 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Blocking Peptide - LS-E7511 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Blocking Peptide - LS-E7512 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Blocking Peptide - LS-E7513 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Blocking Peptide - LS-E7547 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERBB2 / HER2 Antibody Blocking Peptide - LS-E9124 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

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