ERBB2

Gene Symbol	ERBB2
Entrez Gene	2064
Alt Symbol	CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Species	Human
Gene Type	protein-coding
Description	erb-b2 receptor tyrosine kinase 2
Other Description	c-erb B2/neu protein|herstatin|human epidermal growth factor receptor 2|metastatic lymph node gene 19 protein|neuro/glioblastoma derived oncogene homolog|neuroblastoma/glioblastoma derived oncogene homolog|p185erbB2|proto-oncogene Neu|proto-oncogene c-ErbB-2|receptor tyrosine-protein kinase erbB-2|tyrosine kinase-type cell surface receptor HER2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2|v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2|v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Swissprots	B4DHN3 B2RZG3 Q9UMK4 X5D2V5 Q6LDV1 Q14256 P04626
Accessions	AAA35809 AAA35978 AAA58637 AAC37531 AAD15229 AAF30295 AAO18082 BAE15959 BAE15960 CCA94568 CCQ77584 EAW60595 EAW60596 EAW60597 P04626 AB025286 AF177761 AAD56009 AK131568 AK295195 BAG58195 AK296908 BAG59464 AK300321 BAG62073 AK309029 AK313683 BC080193 BC110392 BC156755 AAI56756 BC167147 AAI67147 BI755753 BM678576 CN409735 DC346286 HM437238 ADN43069 HY033940 KJ534831 AHW56471 KJ534832 AHW56472 KJ534964 AHW56604 M11730 AAA75493 S57296 AAD14920 X03363 CAA27060 NM_001005862 NP_001005862 NM_001289936 NP_001276865 NM_001289937 NP_001276866 NM_001289938 NP_001276867 NM_004448 NP_004439 NR_110535
Function	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.
Subcellular Location	Isoform 3: Cytoplasm. Nucleus.
Tissue Specificity	Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth. {ECO:0000269|PubMed:15380516}.
Top Pathways	Proteoglycans in cancer, MicroRNAs in cancer, Central carbon metabolism in cancer, Adherens junction, Calcium signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® HER2/ErbB2 siRNA I - 6282 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® HER2/ErbB2 siRNA II - 6283 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

Neu CRISPR/Cas9 KO Plasmid (h) - sc-400138 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Neu HDR Plasmid (h) - sc-400138-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Neu Double Nickase Plasmid (h) - sc-400138-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Neu Double Nickase Plasmid (h2) - sc-400138-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Neu CRISPR Activation Plasmid (h) - sc-400138-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Neu CRISPR Activation Plasmid (h2) - sc-400138-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Neu Lentiviral Activation Particles (h) - sc-400138-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Neu Lentiviral Activation Particles (h2) - sc-400138-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Neu siRNA (h) - sc-29405 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Neu shRNA Plasmid (h) - sc-29405-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Neu shRNA (h) Lentiviral Particles - sc-29405-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

ErbB2/Her2 RNAi - H00002064-R05 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU078751 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® siRNA - SIHK0725 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0724 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0723 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1020 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1247 from Sigma-Aldrich Category ZFN Kit Prices $6,000.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1020 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05305 from Sigma-Aldrich Category miRNA

ERBB2 siRNA (Human) - CRH1439 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

ErbB2/Her2 RNAi - H00002064-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

ERBB2 - MBS8227357 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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