Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA

• Supplier: Creative Biolabs
• Catalog: AGTO-G022R
• Applications: Cytotoxic Assay FA
• Species Reactivities: Human
• SwissProt/Accession: P04626
• Gene: ERBB2
• Description: This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 scFv to ricin toxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells. Then the ricin A chain is incorporated into the cell by receptor-mediated endocytosis, blocking ribosomal protein synthesis and ultimately leading to cell death. It was designed for treatment of SK-OV-3 tumor xenografts.