Anti-ERBB2 immunotoxin FRP5 (IgG)-Gel

• Supplier: Creative Biolabs
• Catalog: AGTO-G023G
• Applications: Cytotoxic Assay FA
• Species Reactivities: Human
• SwissProt/Accession: P04626
• Gene: ERBB2
• Description: This immunotoxin was achieved by conjugating/fusing the Anti-ERBB2 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to ovarian cancer cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating ovarian Cancer .