PERK Peptide

• Supplier: ABBIOTEC
• Catalog: 350479
• Category: Peptide
• Prices: $50.00
• Sizes: 100 µg
• Purity: Purity > 80% by HPLC
• Gene: EIF2AK3
• Sequence: The synthetic peptide used to raise the antibody Cat. No. 200117 is selected from a sequence within the C-term region of human PERK. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
• Description: PERK, a Ser/Thr protein kinase, phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and to a rapid reduction of translational initiation and repression of global protein synthesis. PERK serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin D1. Defects in PERK are the cause of Wolcott-Rallison syndrome, an early-onset diabetes mellitus.