EIF2AK3

Gene Symbol	EIF2AK3
Entrez Gene	9451
Alt Symbol	PEK, PERK, WRS
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 2-alpha kinase 3
Other Description	PRKR-like endoplasmic reticulum kinase|eukaryotic translation initiation factor 2 alpha kinase 3|hsPEK|pancreatic EIF2-alpha kinase
Swissprots	A0AVH2 Q53SB1 Q53QY0 Q9NZJ5 A0AVH1 B2RCU9 O95846
Accessions	AAF91480 AAY14777 AAY24331 EAW77068 EAW77069 Q9NZJ5 AF110146 AAD19961 AF193339 AAF61199 AI650734 AK128659 BAG54707 AK308312 AK315287 BAG37696 BC040505 BC126354 AAI26355 BC126356 AAI26357 BQ014181 CN285475 CR749382 CAH18234 DA990609 DB287944 XM_005264649 XP_005264706 XR_939749 NM_004836 NP_004827
Function	Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitous. A high level expression is seen in secretory tissues.
Top Pathways	Alzheimer's disease, Protein processing in endoplasmic reticulum, Hepatitis C, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PERK protein fragment - ab101115 from Abcam Category Protein Prices $302.00, $352.00, $1,845.00 Sizes 5 µg, 10 µg, 100 µg Source E. coli Species Human

Human PERK peptide - ab32696 from Abcam Category Peptide

Rat PERK (phospho T980) peptide - ab195519 from Abcam Category Peptide Species Rat

Rat PERK peptide - ab195521 from Abcam Category Peptide Species Rat

EIF2AK3 / PERK Antibody Blocking Peptide - LS-E3378 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EIF2AK3 / PERK Antibody Blocking Peptide - LS-E9458 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PERK Protein - H00009451-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

EIF2AK3-Antibody-N-term-Blocking-Peptide - BP14551a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PERK-Antibody-N-term-Q163-Blocking-Peptide - BP8054a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PERK Blocking Peptide - abx063588 from Abbexa Category Peptide Species Human

EIF2AK3 - H00009451-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

EIF2AK3 - H00009451-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

EIF2AK3 - P5619 from Acris Antibodies Category Protein Prices $840.00 Sizes 5 µg Species Human

EIF2AK3 fusion protein - ag18254 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PERK Peptide - 350479 from ABBIOTEC Category Peptide Prices $50.00 Sizes 100 µg

Recombinant Human EIF2AK3 - EIF2AK3-30644TH from Creative Biomart Category Protein Source E. coli

Recombinant Human Eukaryotic Translation Initiation Factor 2-alpha Kinase 3, GST-tagged - EIF2AK3-1010H from Creative Biomart Category Protein Species Human

Recombinant Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 (EIF2aK3) - RPE975Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 (EIF2aK3) - RPE975Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

PEK, active - 14-916M from EMD Millipore Prices $2,544.00 Sizes 250 µg also available in 10μg size as catalog # 14-916 and in 250 μg as catalog # 14-916-k. Source N-terminal 6His-tagged, recombinant, human PEK amino acids 536 – end, expressed by baculovirus in Sf21 insect cells.

PEK Protein, active, 10 µg - 14-916 from EMD Millipore Category Protein Prices $308.00 Sizes 10 µg also available in 250 µg size - call for pricing and availability and reference catalog numbe Source Human PEK expressed by baculovirus in Sf21 insect cells

PERK Blocking Peptide - CBP2394 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

PERK (R87) Peptide - BS2156P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Eukaryotic translation initiation factor 2-alpha kinase 3(EIF2AK3) ,partial - CSB-YP007512HU CSB-EP007512HU CSB-BP007512HU CSB-MP007512HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EIF2AK3 - TP314993 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Search more