EIF2AK3

Gene Symbol	EIF2AK3
Entrez Gene	9451
Alt Symbol	PEK, PERK, WRS
Species	Human
Gene Type	protein-coding
Description	eukaryotic translation initiation factor 2-alpha kinase 3
Other Description	PRKR-like endoplasmic reticulum kinase|eukaryotic translation initiation factor 2 alpha kinase 3|hsPEK|pancreatic EIF2-alpha kinase
Swissprots	A0AVH2 Q53SB1 Q53QY0 Q9NZJ5 A0AVH1 B2RCU9 O95846
Accessions	AAF91480 AAY14777 AAY24331 EAW77068 EAW77069 Q9NZJ5 AF110146 AAD19961 AF193339 AAF61199 AI650734 AK128659 BAG54707 AK308312 AK315287 BAG37696 BC040505 BC126354 AAI26355 BC126356 AAI26357 BQ014181 CN285475 CR749382 CAH18234 DA990609 DB287944 XM_005264649 XP_005264706 XR_939749 NM_004836 NP_004827
Function	Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Tissue Specificity	Ubiquitous. A high level expression is seen in secretory tissues.
Top Pathways	Alzheimer's disease, Protein processing in endoplasmic reticulum, Hepatitis C, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat EIF2AK3 / PERK ELISA Kit (Cell-Based ELISA) - LS-F2236 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.313-20 ng/ml

Mouse EIF2AK3 / PERK ELISA Kit (Sandwich ELISA) - LS-F9090 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.108 ng/ml Range 0.313-20 ng/ml

Human EIF2AK3 / PERK ELISA Kit (Sandwich ELISA) - LS-F11339 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.313-20 ng/ml

Human pERK ELISA Kit - abx054804 from Abbexa Category ELISA Kit

Eukaryotic translation initiation factor 2-alpha kinase 3, EIF2AK3, Human, ELISA Kit - E11434h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Phospho Extracellular Signal Regulated Kinase, pERK, Human, ELISA Kit - E-EL-H1698 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Phospho-Extracellular Signal-Regulated Kinase, pERK, Mouse, ELISA Kit - E-EL-M0899 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Phospho-Extracellular Signal-Regulated Kinase, PERK, Rat, ELISA Kit - E-EL-R0729 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Phospho Extracellular Signal Regulated Kinase, pERK, Rabbit, ELISA Kit - E-EL-RB1911 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Phospho Extracellular Signal Regulated Kinase, pERK, Chicken, ELISA Kit - E-EL-Ch0795 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Phospho Extracellular Signal Regulated Kinase, pERK, Porcine, ELISA Kit - E-EL-P0607 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Phospho Extracellular Signal Regulated Kinase, pERK, Guinea Pig, ELISA Kit - E-EL-GP1119 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Phospho Extracellular Signal Regulated Kinase, pERK, Monkey, ELISA Kit - E-EL-MK1076 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human PERK ELISA Kit - HP0644 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PERK ELISA Kit - AP0644 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

PEK/PERK Colorimetric Cell-Based ELISA Kit - CB5548 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

pERK (Human) ELISA Kit - DEIA4043 from Creative Diagnostics Category ELISA Kit

Human pERK(Phospho Extracellular Signal Regulated Kinase) ELISA Kit - E-EL-H1698 from Elabscience Category ELISA Kit Sensitivity 18.75 pg/mL Range 31.25—2000 pg/mL

Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3, ELISA Kit - MBS071193 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3, ELISA Kit - MBS069424 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3, ELISA Kit - MBS058684 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3, ELISA Kit - MBS051318 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3, ELISA Kit - MBS068070 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3, ELISA Kit - MBS087532 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3, ELISA Kit - MBS082423 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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