| Gene Symbol |
EIF2AK3
|
| Entrez Gene |
9451
|
| Alt Symbol |
PEK, PERK, WRS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 2-alpha kinase 3
|
| Other Description |
PRKR-like endoplasmic reticulum kinase|eukaryotic translation initiation factor 2 alpha kinase 3|hsPEK|pancreatic EIF2-alpha kinase
|
| Swissprots |
A0AVH2 Q53SB1 Q53QY0 Q9NZJ5 A0AVH1 B2RCU9 O95846
|
| Accessions |
AAF91480 AAY14777 AAY24331 EAW77068 EAW77069 Q9NZJ5 AF110146 AAD19961 AF193339 AAF61199 AI650734 AK128659 BAG54707 AK308312 AK315287 BAG37696 BC040505 BC126354 AAI26355 BC126356 AAI26357 BQ014181 CN285475 CR749382 CAH18234 DA990609 DB287944 XM_005264649 XP_005264706 XR_939749 NM_004836 NP_004827
|
| Function |
Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Ubiquitous. A high level expression is seen in secretory tissues.
|
| Top Pathways |
Alzheimer's disease, Protein processing in endoplasmic reticulum, Hepatitis C, Measles, Influenza A
|