CCND3

Gene Symbol CCND3
Entrez Gene 896
Alt Symbol -
Species Human
Gene Type protein-coding
Description cyclin D3
Other Description D3-type cyclin|G1/S-specific cyclin-D3
Swissprots E9PB36 Q96F49 B2RD63 Q6FG62 B3KQ22 E9PAS4 Q5T8J0 P30281
Accessions AAA51929 AAM51826 EAX04070 EAX04071 EAX04072 EAX04073 EAX04074 EAX04075 EAX04076 P30281 AB209825 BAD93062 AK055519 BAG51531 AK057206 BAG51884 AK096276 BAG53245 AK097856 AK299187 BAG61231 AK303452 BAG64497 AK315421 BAG37810 BC011616 AAH11616 BE247367 BG996045 BX117734 CA424172 CR542246 CAG47042 DA069566 DA411470 DA999482 DB001987 DB104254 DB110132 DB544217 DC360231 DC405843 DQ891748 ABM82674 DQ895130 ABM86056 DR761231 M90814 AAA51927 M92287 AAA52137 XM_011514971 XP_011513273 XM_011514972 XP_011513274 NM_001136017 NP_001129489 NM_001136125 NP_001129597 NM_001136126 NP_001129598 NM_001287427 NP_001274356 NM_001287434 NP_001274363 NM_001760 NP_001751
Function Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15358120}. Cytoplasm {ECO:0000269|PubMed:15358120}. Membrane {ECO:0000269|PubMed:15358120}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways HTLV-I infection, Hippo signaling pathway, PI3K-Akt signaling pathway, Viral carcinogenesis, Measles

Cyclin D3 (DCS22) Mouse mAb - 2936 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (4 western blots), 100 µl (20 western blots)
Host Mouse
Clonality Monoclonal
Clone DCS22
Western blot analysis of extracts from SK-N-MC, C6 and IMCD3 cells, using Cyclin D3 (DCS22) Mouse mAb.

cyclin D3 (C-16) - sc-182 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin D3 (C-16): sc-182. Western blot analysis of cyclin D3 expression in HeLa (A), K-562 (B) and Jurkat (C) phorbol ester-induced nuclear extracts.

cyclin D3 (D-7) - sc-6283 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D3 (D-7): sc-6283. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human prostate carcinoma tissue at low (A) and high (B) magnification showing nuclear staining.

cyclin D3 (18B6-10) - sc-453 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
cyclin D3 (18B6-10): sc-453. Western blot analysis of cyclin D3 expression in nuclear extract prepared from phorbol ester-treated Jurkat cells.

cyclin D3 (H-292) - sc-755 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
cyclin D3 (H-292): sc-755. Western blot analysis of cyclin D3 expression in Jurkat nuclear extract.

cyclin D3 (DCS-22) - sc-56307 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D3 (DCS-22): sc-56307. Western blot analysis of cyclin D3 expression in C6 (A), K-562 (B), PMA treated K-562 (C) and Jurkat (D) whole cell lysates.

cyclin D3 (DCS-28) - sc-56308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
cyclin D3 (DCS-28): sc-56308. Western blot analysis of cyclin D3 expression in K-562 (A), PMA treated K-562 (B), Jurkat (C), PMA treated Jurkat (D) and MOLT-4 (E) whole cell lysates.

cyclin D3 (1) - sc-135875 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
cyclin D3 (1): sc-135875. Western blot analysis of cyclin D3 expression in RSV-3T3 whole cell lysate.

Anti-Cyclin D3 (phospho T283) antibody - ab55322 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
This image shows human lung carcinoma tissue stained with ab55322 at 1/50 dilution. The left hand image shows untreated tissue, the right hand image shows tissue treated with the immunising phosphopeptide.

Anti-Cyclin D3 (phospho T283) antibody - ab182639 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin D3 (phospho T283) antibody (ab182639) at 1/500 dilutionLane 1 : Mouse heart tissue lysate with immunizing peptideLane 2 : Mouse heart tissue lysate

Anti-Cyclin D3 (phospho T283) antibody - ab195999 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin D3 (phospho T283) antibody (ab195999) at 1/500 dilutionLane 1 : UV treated K562 whole cell lysate with antigen specific peptideLane 2 : UV treated K562 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-Cyclin D3 antibody - ab63535 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Cyclin D3 antibody (ab63535) at 1/500 dilutionLane 1 : Extracts from COS7 cells (5-30ug), treated with Forskolin (40nM, 30mins), without immunising peptide.Lane 2 : Extracts from COS7 cells (5-30ug), treated with Forskolin (40nM, 30mins), with immunising peptide (5-10ug).

Anti-Cyclin D3 antibody [DCS-22] - ab150755 from Abcam

Prices $379.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone DCS-22
Immunohistochemical analysis of formalin fixed, paraffin embedded Human tonsil tissue labeling Cyclin D3 with an150755 at 2 µg/ml for 1 hour at room temperature.

Anti-Cyclin D3 antibody [DCS-28.1] (Biotin) - ab79088 from Abcam

Prices $376.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone DCS-28.1
anti-Cyclin D3 at 2 µg/ml + a rat cell lysate

Anti-Cyclin D3 antibody [EP463E] - ab52598 from Abcam

Prices $397.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP463E
Anti-Cyclin D3 antibody [EP463E] (ab52598) at 1/5000 dilution + K562 cell lysate at 10 µgSecondaryHRP-labelled goat anti-rabbit at 1/2000 dilution

Anti-Cyclin D3 antibody [SPM241], prediluted - ab54238 from Abcam

Prices $376.00
Sizes 7 ml
Host Mouse
Clonality Monoclonal
Clone SPM241
Ab54238, prediluted, staining Cyclin D3 in formalin fixed, paraffin embedded human tonsil tissue by immunohistochemistry.

Anti-CCND3 / Cyclin D3 Antibody - LS-C22536 from LifeSpan Bioscience

Prices $605.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody - LS-C22537 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody (aa241-260) - LS-C22540 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody (Azide-free) - LS-C22545 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody - LS-C64103 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal

Anti-CCND3 / Cyclin D3 Antibody (clone DCS-22) - LS-C84868 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone DCS-22

Anti-CCND3 / Cyclin D3 Antibody (clone DCS-22, Azide-free) - LS-C87948 from LifeSpan Bioscience

Prices $590.00, $880.00
Sizes 100 µg, 200 µg
Host Mouse
Clonality Monoclonal
Clone DCS-22

Anti-CCND3 / Cyclin D3 Antibody (clone DCS-28.1, Biotin) - LS-C87950 from LifeSpan Bioscience

Prices $325.00, $705.00, $1,050.00
Sizes 20 µg, 500 µl, 200 µg
Host Mouse
Clonality Monoclonal
Clone DCS-28.1

Anti-CCND3 / Cyclin D3 Antibody (clone DCS-28.1) - LS-C87949 from LifeSpan Bioscience

Prices $280.00, $530.00, $810.00
Sizes 20 µg, 500 µl, 200 µg
Host Mouse
Clonality Monoclonal
Clone DCS-28.1
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