CCND3

Gene Symbol	CCND3
Entrez Gene	896
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cyclin D3
Other Description	D3-type cyclin|G1/S-specific cyclin-D3
Swissprots	E9PB36 Q96F49 B2RD63 Q6FG62 B3KQ22 E9PAS4 Q5T8J0 P30281
Accessions	AAA51929 AAM51826 EAX04070 EAX04071 EAX04072 EAX04073 EAX04074 EAX04075 EAX04076 P30281 AB209825 BAD93062 AK055519 BAG51531 AK057206 BAG51884 AK096276 BAG53245 AK097856 AK299187 BAG61231 AK303452 BAG64497 AK315421 BAG37810 BC011616 AAH11616 BE247367 BG996045 BX117734 CA424172 CR542246 CAG47042 DA069566 DA411470 DA999482 DB001987 DB104254 DB110132 DB544217 DC360231 DC405843 DQ891748 ABM82674 DQ895130 ABM86056 DR761231 M90814 AAA51927 M92287 AAA52137 XM_011514971 XP_011513273 XM_011514972 XP_011513274 NM_001136017 NP_001129489 NM_001136125 NP_001129597 NM_001136126 NP_001129598 NM_001287427 NP_001274356 NM_001287434 NP_001274363 NM_001760 NP_001751
Function	Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15358120}. Cytoplasm {ECO:0000269|PubMed:15358120}. Membrane {ECO:0000269|PubMed:15358120}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}.
Top Pathways	HTLV-I infection, Hippo signaling pathway, PI3K-Akt signaling pathway, Viral carcinogenesis, Measles

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat Phospho-CCND3 / Cyclin D3 (Thr283) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1125 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 78-5000 pg/ml

Mouse/Human/Rat CCND3 / Cyclin D3 ELISA Kit (Cell-Based ELISA) - LS-F1927 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 78-5000 pg/ml

Cyclin-D3, CCND3, Human, ELISA Kit - E-EL-H2094 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin D3, Human, ELISA Kit - E01C0485 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

G1/S-specific cyclin-D3, CCND3, Human, ELISA Kit - E0587h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Cyclin-D3, CCND3, Mouse, ELISA Kit - E-EL-M0383 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Cyclin D3, CCND3, Rat, ELISA Kit - E-EL-R0296 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 18.75 Range 31.25-2000pg/mL

Cyclin-D3, CCND3, Rabbit, ELISA Kit - E-EL-RB2207 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Cyclin-D3, CCND3, Chicken, ELISA Kit - E-EL-Ch0207 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Cyclin-D3, CCND3, Porcine, ELISA Kit - E-EL-P1704 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Cyclin-D3, CCND3, Guinea Pig, ELISA Kit - E-EL-GP1029 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Cyclin-D3, CCND3, Monkey, ELISA Kit - E-EL-MK1210 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human CCND3 ELISA Kit - HC0492 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CCND3 ELISA Kit - AC0492 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Cyclin D3 Colorimetric Cell-Based ELISA Kit - CB5188 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Cyclin D3 (Phospho-Thr283) Colorimetric Cell-Based ELISA Kit - CBP1109 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human CCND3 (Cyclin-D3) ELISA Kit - E-EL-H2094 from Elabscience Category ELISA Kit Range ~0

CCND3, ELISA Kit - MBS2508045 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

CCND3, ELISA Kit - MBS2502737 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CCND3, ELISA Kit - MBS2502749 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CCND3, ELISA Kit - MBS2506405 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

CCND3, ELISA Kit - MBS2513577 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25-2000pg/mL

CCND3, ELISA Kit - MBS2500785 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

CCND3, ELISA Kit - MBS2510266 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

CCND3, ELISA Kit - MBS2504177 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 18.75pg/mL Range 31.25--2000pg/mL

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