| Gene Symbol | CCND3 |
|---|---|
| Entrez Gene | 896 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | cyclin D3 |
| Other Description | D3-type cyclin|G1/S-specific cyclin-D3 |
| Swissprots | E9PB36 Q96F49 B2RD63 Q6FG62 B3KQ22 E9PAS4 Q5T8J0 P30281 |
| Accessions | AAA51929 AAM51826 EAX04070 EAX04071 EAX04072 EAX04073 EAX04074 EAX04075 EAX04076 P30281 AB209825 BAD93062 AK055519 BAG51531 AK057206 BAG51884 AK096276 BAG53245 AK097856 AK299187 BAG61231 AK303452 BAG64497 AK315421 BAG37810 BC011616 AAH11616 BE247367 BG996045 BX117734 CA424172 CR542246 CAG47042 DA069566 DA411470 DA999482 DB001987 DB104254 DB110132 DB544217 DC360231 DC405843 DQ891748 ABM82674 DQ895130 ABM86056 DR761231 M90814 AAA51927 M92287 AAA52137 XM_011514971 XP_011513273 XM_011514972 XP_011513274 NM_001136017 NP_001129489 NM_001136125 NP_001129597 NM_001136126 NP_001129598 NM_001287427 NP_001274356 NM_001287434 NP_001274363 NM_001760 NP_001751 |
| Function | Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15358120}. Cytoplasm {ECO:0000269|PubMed:15358120}. Membrane {ECO:0000269|PubMed:15358120}. Note=Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. {ECO:0000250}. |
| Top Pathways | HTLV-I infection, Hippo signaling pathway, PI3K-Akt signaling pathway, Viral carcinogenesis, Measles |