IRF7

Gene Symbol	IRF7
Entrez Gene	3665
Alt Symbol	IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H
Species	Human
Gene Type	protein-coding
Description	interferon regulatory factor 7
Other Description	IRF-7|interferon regulatory factor-7H
Swissprots	Q9UE79 O00332 Q92985 B9EGL3 O00331 O75924 O00333
Accessions	AAG30003 EAX02355 EAX02356 EAX02357 EAX02358 EAX02359 EAX02360 Q92985 AF076494 AAC70999 AK303752 BAG64723 BC136555 AAI36556 BC144242 BM849172 DA601567 DA967682 KC477210 AGI78456 U53830 AAB80686 U53831 AAB80688 U53832 AAB80690 U73036 AAB17190 XM_005252906 XP_005252963 XM_005252907 XP_005252964 XM_005252908 XP_005252965 XM_005252909 XP_005252966 XM_006725137 XP_006725200 XM_006725138 XP_006725201 XM_006725139 XP_006725202 XM_011520066 XP_011518368 NM_001572 NP_001563 NM_004029 NP_004020 NM_004031 NP_004022 NM_004030
Function	Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear locali
Subcellular Location	Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
Tissue Specificity	Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
Top Pathways	Hepatitis C, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IRF7 peptide - ab24662 from Abcam Category Peptide

Human IRF7 peptide - ab92594 from Abcam Category Peptide Species Human

IRF7 Antibody Blocking Peptide - LS-E30274 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IRF7 Antibody Blocking Peptide - LS-E30275 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

IRF7 Antibody Blocking Peptide - LS-E13802 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRF7 Antibody Blocking Peptide - LS-E13801 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

IRF7 Blocking Peptide - NBP1-77264PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IRF7 Blocking Peptide - NBP1-77263PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

IRF7 Peptide - GTX85489-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

IRF7 Peptide - GTX85490-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

IRF7 Control Peptide - AP30449CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

IRF7 Peptide - 3941P from ProSci Category Peptide Species Human

IRF7 Peptide - 3943P from ProSci Category Peptide Species Human

IRF7 fusion protein - ag18059 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

IRF7 fusion protein - ag19189 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Interferon regulatory factor 7(IRF7) - CSB-YP011822HU CSB-EP011822HU CSB-BP011822HU CSB-MP011822HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IRF-7 Peptide - abx165248 from Abbexa Category Peptide Species Human, Mouse, Rat

IRF7 (transcript variant a) - TP317934 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

IRF7 Recombinant Protein Antigen - NBP2-38678PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IRF7 Peptide, Human - M34GP07744H from Creative Peptides Category Peptide Source Synthetic. Species Human

Interferon regulatory factor 7 (IRF7), Recombinant Protein - MBS1452405 from MyBioSource Category Protein Prices $1,290.00, $1,290.00, $1,510.00, $1,510.00, $2,120.00, $2,120.00, $2,585.00, $2,585.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more