IRF7

Gene Symbol	IRF7
Entrez Gene	3665
Alt Symbol	IRF-7H, IRF7A, IRF7B, IRF7C, IRF7H
Species	Human
Gene Type	protein-coding
Description	interferon regulatory factor 7
Other Description	IRF-7|interferon regulatory factor-7H
Swissprots	Q9UE79 O00332 Q92985 B9EGL3 O00331 O75924 O00333
Accessions	AAG30003 EAX02355 EAX02356 EAX02357 EAX02358 EAX02359 EAX02360 Q92985 AF076494 AAC70999 AK303752 BAG64723 BC136555 AAI36556 BC144242 BM849172 DA601567 DA967682 KC477210 AGI78456 U53830 AAB80686 U53831 AAB80688 U53832 AAB80690 U73036 AAB17190 XM_005252906 XP_005252963 XM_005252907 XP_005252964 XM_005252908 XP_005252965 XM_005252909 XP_005252966 XM_006725137 XP_006725200 XM_006725138 XP_006725201 XM_006725139 XP_006725202 XM_011520066 XP_011518368 NM_001572 NP_001563 NM_004029 NP_004020 NM_004031 NP_004022 NM_004030
Function	Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear locali
Subcellular Location	Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
Tissue Specificity	Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
Top Pathways	Hepatitis C, Toll-like receptor signaling pathway, Cytosolic DNA-sensing pathway, Measles, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® IRF-7 siRNA I - 13139 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® IRF-7 siRNA II - 13291 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

IRF-7 CRISPR/Cas9 KO Plasmid (h) - sc-400450 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 HDR Plasmid (h) - sc-400450-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 Double Nickase Plasmid (h) - sc-400450-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 Double Nickase Plasmid (h2) - sc-400450-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 CRISPR Activation Plasmid (h) - sc-400450-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 CRISPR Activation Plasmid (h2) - sc-400450-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 Lentiviral Activation Particles (h) - sc-400450-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 Lentiviral Activation Particles (h2) - sc-400450-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 siRNA (h) - sc-38011 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRF-7 shRNA Plasmid (h) - sc-38011-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRF-7 shRNA (h) Lentiviral Particles - sc-38011-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRF7 RNAi - H00003665-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

IRF7 RNAi - H00003665-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU122971 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2003 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2003 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

IRF7 siRNA (Human) - CRH2458 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IRF7 RNAi - H00003665-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

IRF7 RNAi - H00003665-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

IRF7 - MBS8229782 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IRF-7 CRISPR/Cas9 KO Plasmid (h2) - sc-400450-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRF-7 HDR Plasmid (h2) - sc-400450-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human IRF7 (NM_001572.3) - SHH320653 from Creative biogene Category siRNA Species Reactivities Human

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