UBA2

Gene Symbol	UBA2
Entrez Gene	10054
Alt Symbol	ARX, HRIHFB2115, SAE2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like modifier activating enzyme 2
Other Description	SUMO-1 activating enzyme subunit 2|SUMO-activating enzyme subunit 2|SUMO1 activating enzyme subunit 2|UBA2, ubiquitin-activating enzyme E1 homolog|anthracycline-associated resistance ARX|ubiquitin-like 1-activating enzyme E1B|ubiquitin-like modifier-activating enzyme 2
Swissprots	O95605 Q6IBP6 Q59H87 Q9UED2 Q9NTJ1 B3KWB9 Q9UBT2
Accessions	Q9UBT2 AB015337 BAA34795 AB208872 BAD92109 AF079566 AAD23914 AF090384 AAD12784 AF110957 AAD24434 AK023120 BAG51158 AK024114 BAG51265 AK124730 BAG54081 AK299514 BAH13056 AK315521 BAG37902 AL136905 CAB66839 BC003153 AAH03153 BG503066 BG678201 BM556031 BT009781 AAP88783 CR456756 CAG33037 DQ893423 ABM84349 EU176757 ABW03558 U35832 AAC99992 XM_005258404 XP_005258461 XM_006722962 XP_006723025 XM_011526304 XP_011524606 XR_935712 NM_005499 NP_005490
Function	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SAE2 / UBA2 ELISA Kit (Cell-Based ELISA) - LS-F2374 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

ubiquitin-like modifier activating enzyme 2, ELISA Kit - MBS9317388 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.25 ng/ml - 8 ng/ml.

Uba2 Colorimetric Cell-Based ELISA Kit - CB5712 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Uba2 ELISA Kit - DEIA-XYA1810 from Creative Diagnostics Category ELISA Kit

Human UBA2 ELISA Kit - E097120 from Biobool Category ELISA Kit

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9352708 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9352956 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9361495 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9369127 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9361748 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9354957 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9358620 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9356877 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9368867 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9348013 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9367292 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9368944 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9358615 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9345635 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9346279 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9348930 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9379831 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9348179 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9353636 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SUMO-Activating Enzyme Subunit 2 (UBA2), ELISA Kit - MBS9368476 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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